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07-09-2010, 03:14 PM
So recently, I was told that when using regression with interactions, a main term must always be put in the model. I brought up a situation where I thought you might not need to use a main term, but was told you still have to. Thought I'd share it with you guys to see what you think.
Picture a clinical trial. A control and a treatment group are formed that are exchangeable. The outcome of interest (lets say height) is exactly the same between the two groups. You want to see how the treatment affects height over time (i.e. repeated measures). A model you could set up is:
E[Y] = B0 + B1(Time) + B2(group) + B3(Time*group)
My argument was that since you've verified that both groups start with the same measure of the dependent variable, there is no need to at in the main term for group (i.e. B2(group)). You'd really just be interested in the interaction. I was told that the interpretation of interaction still requires you to have two beta coefficients though.
Do you guys agree?
PS. I know that there will be correlation from the repeated measures. That's a separate issue that I'm conveniently ignoring for now though.
Picture a clinical trial. A control and a treatment group are formed that are exchangeable. The outcome of interest (lets say height) is exactly the same between the two groups. You want to see how the treatment affects height over time (i.e. repeated measures). A model you could set up is:
E[Y] = B0 + B1(Time) + B2(group) + B3(Time*group)
My argument was that since you've verified that both groups start with the same measure of the dependent variable, there is no need to at in the main term for group (i.e. B2(group)). You'd really just be interested in the interaction. I was told that the interpretation of interaction still requires you to have two beta coefficients though.
Do you guys agree?
PS. I know that there will be correlation from the repeated measures. That's a separate issue that I'm conveniently ignoring for now though.