Statistics Help @ Talk Stats Forum - Biostatistics
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Epidemiology and biostatistics, public health research. GLM, logistic regression, survival analysis, clinical trials.enMon, 27 Feb 2017 22:28:10 GMTvBulletin60http://www.talkstats.com/images/misc/rss.pngStatistics Help @ Talk Stats Forum - Biostatistics
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Testing for trend
http://www.talkstats.com/showthread.php/68791-Testing-for-trend?goto=newpost
Sat, 25 Feb 2017 14:25:55 GMTI have following data that represent number of new patients with rare disease for subsequent 5 year time periods: 4, 3, 4, 2, 4, 2, 4, 6, 11
As I...I have following data that represent number of new patients with rare disease for subsequent 5 year time periods: 4, 3, 4, 2, 4, 2, 4, 6, 11

As I can see, there is an increasing trend. Is there more appropriate way to test for significance of trend in this situation than Spearman correlation?

I also have data on patient basis (year of diagnosis for each patient).
]]>BiostatisticsMarkica85http://www.talkstats.com/showthread.php/68791-Testing-for-trendTest negative factors among correlated determinants
http://www.talkstats.com/showthread.php/68787-Test-negative-factors-among-correlated-determinants?goto=newpost
Sat, 25 Feb 2017 05:05:56 GMTDear all,
I am working on the obesity research. I found a molecule A that is negatively control the generation of adipocytes. I have a cohort of...Dear all,

I am working on the obesity research. I found a molecule A that is negatively control the generation of adipocytes. I have a cohort of patients, and collected their adipose tissue samples (n=29). I do found that A is negatively correlated with adipogenesis in lean patients (n=22). However, A is strongly correlated with obesity, and in obesity people (n=7), both adipogenesis and A is increased. I can not tell the effect of A on adipogenesis in those patients.

I tried multiple lineage regression on total samples, but it worked badly. I am going to try partially least square, do you think it is a appropriate way? Whether there is a better statistic model can deal with this situation?

Thanks a lot for your time. I appreciate any suggestions and comments.
]]>Biostatisticspinetophttp://www.talkstats.com/showthread.php/68787-Test-negative-factors-among-correlated-determinants