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Forum: Biostatistics

Epidemiology and biostatistics, public health research. GLM, logistic regression, survival analysis, clinical trials.

  1. Estimating main effects in a two factorial log linear model when applied to RNA-seq

    Hi everybody, I'm going to apply multiDE, an R package for detection of DEG in multiple treatment conditions, on some RNA-seq time series data......

    Started by Fate.gh‎, 09-16-2016 02:29 PM
    log-linear, rna-seq
    • Replies: 0
    • Views: 188
    09-16-2016, 02:29 PM Go to last post
  2. Survival analysis

    Hi there, I am doing some breast cancer survival analysis on population-based registry data...I have outlined to estimate incidence trends and...

    Started by MAYA85‎, 09-15-2016 02:28 PM
    • Replies: 2
    • Views: 167
    09-16-2016, 04:20 AM Go to last post
  3. What test to use?

    Hi all, I am new to statistics. Now, I am doing a research but I don't know which test to use. Basically, I have four groups with both positive...

    Started by Upupgo‎, 09-14-2016 01:50 PM
    • Replies: 1
    • Views: 116
    09-14-2016, 02:54 PM Go to last post
  4. Question R caret package: problems understanding the functions in confusionMatrix

    Hey, I earlier posted about the problematic interpretation of PPV (positive predictive value). As there seems to be no easy solution for that I...

    Started by lilchaos‎, 09-02-2016 08:17 AM
    • Replies: 2
    • Views: 211
    09-13-2016, 01:44 AM Go to last post
  5. Talking Analysing pre- and post-treatment lactate curves

    Good morning all, Has anyone got experience with analysing lactate against power curves? I have pre- and post-treatment lactate curves for 10...

    Started by WildlifeStats‎, 09-12-2016 03:21 AM
    curve, curves
    • Replies: 0
    • Views: 77
    09-12-2016, 03:21 AM Go to last post
  6. [SPSS - post hoc analysis and Logistic regression] When the result don't line up

    I'm a medical student doing his research interneship. We're currently investigating if there's a link between motoric and mental outcome and MRI...

    Started by j0hnj0hn‎, 09-08-2016 05:34 AM
    fisher exact test, logistic regression, medicine, post hoc tests
    • Replies: 0
    • Views: 146
    09-08-2016, 05:34 AM Go to last post
  7. How to evaluate significance.

    Hi, I have 58 samples and an enrichment analysis was done to each of them. So for each sample I have a list of enriched terms. I've collected the...

    Started by MinieMe‎, 09-06-2016 11:14 AM
    • Replies: 0
    • Views: 152
    09-06-2016, 11:14 AM Go to last post
  8. ROC curve cutoff not significant, but it works

    I'm dealing with a numerical variable and its prognostic significance in a sample of cancer patients. I'm trying to find an optimal cutoff point for...

    Started by Markica85‎, 09-04-2016 07:05 AM
    • Replies: 4
    • Views: 291
    09-04-2016, 01:14 PM Go to last post
  9. How to analyze this data

    Hello, I need guidance in analyzing the outcome. I have 4 independent variables, and 2 dependent variables. The sample size is ~600. I...

    Started by reddy‎, 09-01-2016 03:22 PM
    statistical methods
    • Replies: 1
    • Views: 138
    09-02-2016, 03:46 AM Go to last post
  10. Help deciding paired vs unpaired t-test

    Hi, I am analyzing an experiment in which protein levels were examined in two different strains of bacteria. Lets call them A and B. Three...

    Started by abbey‎, 09-01-2016 01:37 PM
    comparison, t-test
    • Replies: 2
    • Views: 119
    09-01-2016, 02:19 PM Go to last post
  11. Help decide on appropriate test for experiment design

    Hello - new to the forums here! I work in cell biology and a colleague and I are designing an experiment to determine the appropriate...

    Started by Dan Kordella‎, 08-11-2016 01:04 PM
    • Replies: 5
    • Views: 327
    08-30-2016, 04:01 PM Go to last post
  12. Positive predictive value of biased data

    Hey, I am currently dealing with prediction of binary data due to structural alerts. This means if a substructure is within the query structure it...

    Started by lilchaos‎, 08-29-2016 03:03 AM
    • Replies: 2
    • Views: 139
    08-30-2016, 01:21 AM Go to last post
  13. Matched Groups Statistics

    Hello all hope this is the right thread for the question and that someone will be able to help me out :confused: I have created a propensity...

    Started by summit cross‎, 08-29-2016 03:21 AM
    matched, matched controls, propensity score matching, regression analysis
    • Replies: 2
    • Views: 133
    08-29-2016, 01:42 PM Go to last post
  14. I need advice on Fisher's exact test

    I recently submitted a paper and in my study, I wanted to see if there is an association between a gene mutation and the absence/presence of the...

    Started by Coral‎, 08-25-2016 03:58 AM
    • Replies: 4
    • Views: 237
    08-29-2016, 03:50 AM Go to last post
  15. calculate p value significance

    How to calculate p value significance for the following? We educated 334 individuals over the age of 50 about cancer. 87 (26.05%) of them made...

    Started by deepbiomed‎, 08-26-2016 11:24 AM
    #cancer #education effect
    • Replies: 2
    • Views: 203
    08-27-2016, 06:48 AM Go to last post
  16. Help on Bhapkar's Test using SAS/R/SPSS?

    Hi All, I am currently wandering in the unfamiliar territory of the Bhapkar's test, and hopefully someone can provide some guidance... Please see...

    Started by lennexyu‎, 08-19-2016 01:24 AM
    • Replies: 3
    • Views: 320
    08-22-2016, 09:47 PM Go to last post
  17. Help with statistical power?

    Hi, I'm doing a study looking at the ability of a test to detect a change in bacterial numbers pre- versus post-treatment . I've done a chi-square...

    Started by mgzx‎, 08-20-2016 10:42 PM
    chi-square, power, sample size, significance
    • Replies: 2
    • Views: 174
    08-21-2016, 03:01 AM Go to last post
  18. Graphpad or SPSS way to analyze this question

    Dear friends, I have ~3500 patients. I have ages for everyone of them, and i have a laboratory value for each one as well. I want to know if the...

    Started by docoftheworld‎, 08-15-2016 10:14 AM
    • Replies: 4
    • Views: 225
    08-15-2016, 08:48 PM Go to last post
  19. some urgent help

    dear all I'm in need for the solution of chapter 7 ,8 and 9 of the book (Fundamentals of Biostatistics S e v e n t h E d i t i o n Bernard...

    Started by dafer‎, 08-15-2016 05:42 AM
    • Replies: 1
    • Views: 144
    08-15-2016, 08:46 AM Go to last post
  20. Fisher Test for 5x2 table with SAS or R

    Hi, I wish to perform a Fisher Test for a 5x2 contingency table. I have a patient population divided in to 5 treatment groups, each with a...

    Started by BioStatNoob‎, 08-12-2016 07:43 AM
    • Replies: 3
    • Views: 184
    08-13-2016, 11:38 PM Go to last post
  21. How to obtain an unbiased post-stratified estimator for survival probabilities?

    Suppose I have estimated the survival probabilities $\hat{S(t)}_1, \hat{S(t)}_2, \ldots, \hat{S(t)}_H$ from $H$ strata. Now I want to get an unbiased...

    Started by Blain Waan‎, 08-12-2016 08:14 PM
    estimator, stratification, survival
    • Replies: 1
    • Views: 180
    08-13-2016, 09:24 AM Go to last post
  22. Repeated Measures Analysis with a long baseline period

    I am currently attempting to analyze the efficacy of a treatment on a premature baby's SpO2 levels. I have many measurements before the treatment...

    Started by Nives_ES‎, 08-08-2016 10:41 AM
    • Replies: 0
    • Views: 181
    08-08-2016, 10:41 AM Go to last post
  23. Mean and SD of two means and SD

    If we have two groups of males, group 1: age >60 and group 2 <60. each of these groups have mean and SD; can we calculate a mean and SD for all...

    Started by docoftheworld‎, 08-02-2016 10:08 AM
    • Replies: 13
    • Views: 509
    08-04-2016, 11:36 PM Go to last post
  24. Beginner questions: Clinical trial

    Hi there! I am a medical student working on my PhD, and I am analyzing some data for a meeting. Since we don't learn much about statistics (at...

    Started by Queen_in_the_North‎, 08-03-2016 02:37 PM
    beginner, correlation, pspp, significance, t-test
    • Replies: 0
    • Views: 163
    08-03-2016, 02:37 PM Go to last post
  25. Interpreting odds ratio in ordinal logistic regression

    Hi All, My data is from an educational programme for students. Questionnaire data was collected pre-intervention and post-intervention. We are...

    Started by lennexyu‎, 08-01-2016 08:54 PM
    • Replies: 2
    • Views: 227
    08-03-2016, 01:31 AM Go to last post
  26. Question Is this the right away to perform a trend analysis in a r*c table?

    I might be not posting the question in the right forum since I didn't get any advice so far (after 20 viewers) and my project is a public health one,...

    Started by belindalimm‎, 07-29-2016 04:19 PM
    • Replies: 1
    • Views: 197
    08-01-2016, 01:01 PM Go to last post
  27. Intrarater reliability for continuous variable

    I was hopeful for some advice on how to assess intrarater (not inter) reliability. My specific problem is 1 rater repeats a measurement on 20...

    Started by viostorm‎, 07-30-2016 11:25 AM
    • Replies: 2
    • Views: 223
    07-30-2016, 12:22 PM Go to last post
  28. SAS Coding to find averages for every 60 observations

    Hi. I am working on an analysis for research on premature baby health. I ran into a SAS coding issue which I hope some of you can help me with. ...

    Started by Nives_ES‎, 07-28-2016 10:26 AM
    sas mean research coding
    • Replies: 10
    • Views: 312
    07-29-2016, 01:38 PM Go to last post
  29. Paired or Unpaired T-test?

    If I have traps set to capture a certain animal at night vs. during the day, would I use a paired or unpaired T-test? I'd be comparing the mean...

    Started by OMai‎, 05-22-2016 10:59 AM
    paired, t-test, unpaired
    • Replies: 3
    • Views: 337
    07-28-2016, 03:22 PM Go to last post
  30. Cox's regression

    Hello, I have some experimental data for animals with tumours. Unfortunately, they were not followed individually during a time course, but...

    Started by confused1‎, 07-27-2016 06:03 AM
    biostatistics, cancer, cox, regression, survival
    • Replies: 0
    • Views: 259
    07-27-2016, 06:03 AM Go to last post
  31. starting in biostats and need to analyse clinical data. how to begin.

    Hello everybody I am a very beginer in stats and in using SPSS. I need to analyse some clinical data. I want to know please if this is a good...

    Started by Stat_begi‎, 07-22-2016 02:21 PM
    • Replies: 1
    • Views: 310
    07-22-2016, 03:54 PM Go to last post
  32. Which statistical approach?

    Dear all, I am a biologist with a very poor statistical knowledge so please excuse me if my question is not very well formulated- I am doing my best...

    Started by Nessie‎, 07-18-2016 08:57 AM
    gene related
    • Replies: 4
    • Views: 389
    07-18-2016, 09:41 AM Go to last post
  33. Correct analysis of crossover trials

    Hi everybody I was wondering if anyone here had any expertise regarding analysis of crossover trials. I'm writing my thesis at the moment and...

    Started by TNK78‎, 07-18-2016 06:56 AM
    analysis, crossover trial, treatment sequence
    • Replies: 1
    • Views: 170
    07-18-2016, 08:29 AM Go to last post
  34. Author's interpretation of Odds Ratio and Confidence intervals

    Hi all, Having some difficulty understanding the results of this paper I am including in a review. It compares the effects of 3 interventions...

    Started by crkc‎, 07-16-2016 07:23 AM
    confidence interval, intervention, odds ratio, significance
    • Replies: 1
    • Views: 191
    07-16-2016, 08:16 AM Go to last post
  35. What does a mean probability mean?

    Hi all. If each case in a dataset is assigned a probability of a certain event having occurred (based on their own individual data) and I...

    Started by blue11‎, 07-13-2016 06:09 PM
    • Replies: 1
    • Views: 237
    07-13-2016, 07:05 PM Go to last post
  36. Computing age and gender standardised mean BMI

    Hi, I'll appreciate a lot if someone could tell me how to compute age and gender standardised mean BMI in stata. Thanks. ZZ

    Started by Zain Zaid‎, 07-10-2016 08:20 PM
    • Replies: 0
    • Views: 328
    07-10-2016, 08:20 PM Go to last post
  37. Please help interpret cross-sectional study results (odds ratio, relevant risk, etc.)

    I'm trying to help my wife with some statistics. She's looking to see if people with Removable Dentures (RD) have a higher prevalence of Combination...

    Started by jbbuck‎, 07-08-2016 04:32 PM
    confidence interval, cross-sectional study, odds ratio, relative risk
    • Replies: 1
    • Views: 262
    07-09-2016, 03:35 AM Go to last post
  38. Lightbulb power calculation for two groups (parallel)

    Hi I have got 400 and 600 samples in control and test groups respectively. And in each of these two groups, i have an effect variable that occurs at...

    Started by rony443‎, 07-08-2016 02:01 AM
    power analysis, sample size
    • Replies: 2
    • Views: 214
    07-08-2016, 10:54 AM Go to last post
  39. SPSS, descriptive statistics, crosstabs, risk

    the problem has been solved. thanks

    Started by Menekse‎, 07-07-2016 03:36 AM
    • Replies: 0
    • Views: 196
    07-07-2016, 03:36 AM Go to last post
  40. Parallel Bioequivalence Study Sample Size

    I need to calculate the required sample size given the following information: Power=80% Coefficient of variation for Cmax and AUC = 40% True...

    Started by gopher‎, 07-04-2016 03:26 AM
    bioequivalence, sample size calculation
    • Replies: 0
    • Views: 279
    07-04-2016, 03:26 AM Go to last post
  41. Question How to prove two methods are “similar”?

    We are testing two imaging machines. One of the machines has been validated numerous times. However, we built the new machine and we need to prove...

    Started by yolo123‎, 07-01-2016 09:40 AM
    physics, research, statistics, validation
    • Replies: 1
    • Views: 328
    07-01-2016, 10:40 AM Go to last post
  42. External Validation of Cox Model

    I have two data set (training and validation) for building and validating a Cox model. With the training data set I fitted a cox model using...

    Started by Jyde‎, 06-28-2016 05:17 AM
    cox proportional hazard, sas clinical, survival analysis, validation
    • Replies: 8
    • Views: 507
    06-29-2016, 04:18 AM Go to last post
  43. Help interpreting an interaction in Binary Logistic Regression

    Firstly, thank you for taking the time to read my problem that I am having. The goal: interpret the direction of the interaction term. ...

    Started by 2+2=5‎, 06-25-2016 09:50 AM
    interaction effect, logisitic regression, logistic interaction
    • Replies: 3
    • Views: 346
    06-25-2016, 04:05 PM Go to last post
  44. Calculating standard deviation from mean and P value

    I am doing a systematic review and one of the papers I am including has reported the data only as mean, sample size and P value. I need the mean and...

    Started by CMP‎, 06-22-2016 03:35 PM
    • Replies: 10
    • Views: 575
    06-24-2016, 10:10 AM Go to last post
  45. Permutation correlation with one non-normal variable

    Hi, I am trying to assess the relationship between a relatively normally distributed variable (brain volume) and a strongly right-skewed...

    Started by nielsl‎, 06-23-2016 03:06 AM
    correlation, pearson, permutation
    • Replies: 1
    • Views: 236
    06-24-2016, 02:45 AM Go to last post
  46. Computing effect size with adverse event counts?

    Hello! I'm working on a meta-analysis, and I have a special problem regarding effect size. Can anyone lend me some insight? I have a treatment...

    Started by wag‎, 03-14-2016 02:26 PM
    • Replies: 1
    • Views: 440
    06-22-2016, 05:34 PM Go to last post
  47. Triple crossover study and multivariate model with paired data

    Hi, I would like to analyze data from a triple crossover study. Same population received same drug (or placebo) three times a day with...

    Started by Markica85‎, 05-28-2016 03:51 AM
    • Replies: 1
    • Views: 390
    06-21-2016, 06:50 AM Go to last post
  48. Question Statistical Approach for data (uneven intervals)

    Hello, What statistical approach would you recommend for a data of the following pattern. In a 12-hour window, each row/ID is an independent...

    Started by rvr‎, 06-20-2016 12:23 PM
    frequency distribution, model selection, statistical approach, time interval, uneven tests taken
    • Replies: 0
    • Views: 241
    06-20-2016, 12:23 PM Go to last post
  49. Test for ordinal DV in mixed design

    What's the corresponding test to Two way Mixed ANOVA when the DV is ordinal? I have two treatment groups, 14 time points and the DV is an ordinal...

    Started by Logician‎, 06-14-2016 06:55 PM
    • Replies: 0
    • Views: 565
    06-14-2016, 06:55 PM Go to last post
  50. How to construct a scatter graph with percentiles lines

    Good day, How to construct a scatter graph with percentiles lines, like the one in the image below, with any program ?

    Started by tonia bird‎, 06-04-2016 01:35 PM
    • Replies: 3
    • Views: 607
    06-11-2016, 06:13 PM Go to last post
  51. Repeatability and Logistic Regression?

    Hi all, my stats knowledge is quite basic so I would appreciate any help you can provide! I am working on a study looking at inter-grader and...

    Started by StatsN00bie‎, 06-10-2016 01:04 PM
    • Replies: 2
    • Views: 351
    06-10-2016, 02:02 PM Go to last post
  52. Is this study a case-control or retrospective cohort?

    "Recently we retrospectively examined the spine on pyelograms of 34 children with Wilms tumour. The findings were compared with those obtained in 148...

    Started by klionj‎, 06-02-2016 11:44 PM
    • Replies: 0
    • Views: 309
    06-02-2016, 11:44 PM Go to last post
  53. Significance of a Dichotomous Variable Over a Continuous Variable

    Hi all! I ran an analysis using the 2005 healthy eating index (HEI) score as the dependent variable and am a bit confused by my results. The HEI...

    Started by tnrose87‎, 05-31-2016 07:12 PM
    • Replies: 1
    • Views: 298
    06-01-2016, 06:24 AM Go to last post
  54. Chi Square for Molecular Screening Comparison

    Hi, I'm trying to run a chi square test to compare two different screening methods for a pathogen. I'm testing this by diluting a known positive...

    Started by OMai‎, 05-31-2016 03:59 PM
    • Replies: 0
    • Views: 183
    05-31-2016, 03:59 PM Go to last post
  55. Best Statistical test for data

    Hi All, Just wondering if someone could help with an issue with my data. I am wanting to analyse the relationship between continuous variable...

    Started by HRS‎, 05-25-2016 03:48 AM
    • Replies: 3
    • Views: 418
    05-26-2016, 06:49 AM Go to last post
  56. ANCOVA assmptions not met.

    Hi, What is the non parametric alternative for parametric ANCOVA if we find that some ANCOVA assumptions are not met? How it can be done in SAS?

    Started by shruti verma‎, 05-25-2016 03:46 AM
    analysis, analysis of covariance, ancova, assumptions
    • Replies: 1
    • Views: 217
    05-25-2016, 04:03 AM Go to last post
  57. Score methods

    Hello everyone, I would like your opinion. my data is score (before and after therapy) on radiographs made with x-ray instrument and score based on...

    Started by andrew_fg‎, 05-23-2016 01:47 PM
    • Replies: 2
    • Views: 284
    05-24-2016, 01:55 PM Go to last post
  58. Please help me selecting a test for my study

    Hi, I was wondering if you guys can provide some ideas on best test for my samples size, since I am not very stat savvy. My project consist of...

    Started by kite6k‎, 05-18-2016 12:07 PM
    • Replies: 4
    • Views: 362
    05-24-2016, 09:03 AM Go to last post
  59. Frequency analysis

    Hello. I have a problem with my analysis. I got 2 groups which take drug (Group 1 (50 people) takes real medicine and Group 2 (40 people) takes...

    Started by Makina‎, 05-20-2016 04:50 AM
    • Replies: 7
    • Views: 492
    05-23-2016, 08:12 AM Go to last post
  60. Non parametric multivariate analysis. maybe :(

    Hello to everyone, i need some help with my statistical analysis. I have two different pharmacokinetic parameters. They result from two different...

    Started by bluina‎, 05-11-2016 03:38 AM
    biostatistics, multivariate analysis, non parametric
    • Replies: 4
    • Views: 435
    05-20-2016, 04:07 AM Go to last post

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