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Forum: Biostatistics

Epidemiology and biostatistics, public health research. GLM, logistic regression, survival analysis, clinical trials.

  1. Non-parametric alternative to repeated-measures ANOVA with a between-subjects factor?

    Hello, I'm trying to do a repeated-measures ANOVA but my data is likely violating the multivariate normality assumption. My question is: Does...

    Started by PHO_M‎, 08-15-2012 04:19 PM
    • Replies: 4
    • Views: 4,161
    08-17-2012, 07:50 AM Go to last post
  2. Gene expression analysis - FDR and p-values

    Hi, I'm using Affymetrix microarrays to check if there exist some differences in the gene expression of two group of animals that have been...

    Started by jma‎, 08-07-2012 09:30 AM
    • Replies: 4
    • Views: 1,755
    08-17-2012, 04:34 AM Go to last post
  3. Fixed effects vs. Random Effects

    Hi we had 5 investigators 1)hand out 100 surveys and 2)record a certain feature of each of the 100 subjects. That feature that they recorded is the...

    Started by wuzzy‎, 08-15-2012 11:27 AM
    fixed, random
    • Replies: 1
    • Views: 459
    08-16-2012, 08:32 PM Go to last post
  4. Which test should I use to compare these two groups?

    Hi everybody. I have two groups of doctors, group A and group B. I'm trying to see if there is any statistical difference between them in their...

    Started by MadDoc‎, 08-16-2012 07:11 AM
    • Replies: 8
    • Views: 577
    08-16-2012, 02:58 PM Go to last post
  5. Bisulfite Sequencing - Is a t-test enough?

    Hey everybody, I am a plant molecular biologist doing some bisulfite sequencing. I am currently using a t-test on my data, but I feel like that...

    Started by diowulf‎, 08-13-2012 03:25 PM
    • Replies: 0
    • Views: 376
    08-13-2012, 03:25 PM Go to last post
  6. Post Job: Health Economist/Economitrician/Biostatistician Required

    Health Economist Introduction This is an opportunity to work for an international company specialising in Health Economics, Patient-Reported...

    Started by abhijeetroy‎, 08-13-2012 05:37 AM
    biostatistician, career, econometrics, health economist, jobs
    • Replies: 0
    • Views: 392
    08-13-2012, 05:37 AM Go to last post
  7. Post Estimates

    Compare point estimate to interval estimate

    Started by 0302‎, 08-10-2012 04:21 AM
    • Replies: 2
    • Views: 381
    08-10-2012, 07:14 PM Go to last post
  8. Durbin-Watson Test

    Hi, I'm looking to analyse some vigilance data from monkeys. The data at the moment comes from 5minute samples, but these are separated depending...

    Started by mr_bennyc‎, 08-09-2012 07:19 AM
    • Replies: 3
    • Views: 477
    08-09-2012, 11:49 AM Go to last post
  9. ANCOVA violating assumptions

    Hi, The data I'm looking to analyse is vigilance data from monkeys. I need to investigate which factors affect the different types of vigilance....

    Started by mr_bennyc‎, 08-08-2012 12:02 PM
    ancova, general linear model, normality, variance
    • Replies: 0
    • Views: 359
    08-08-2012, 12:02 PM Go to last post
  10. Forecasting "half-time", which method?

    My problem: My data is a time-series of watersamples taken daily. The water have a concentration of a toxic pollution and I want to forecast the...

    Started by sellingforsale‎, 08-08-2012 08:11 AM
    • Replies: 0
    • Views: 283
    08-08-2012, 08:11 AM Go to last post
  11. Is this study clinical trial or retrospective cohort?

    Hi We have a set of patients with dental implants in their mouths. We wanna evaluate whether implants in each patient's mouth are as sensitive as...

    Started by victorxstc‎, 07-13-2011 07:43 AM
    clinical trial, retrospective study
    • Replies: 13
    • Views: 2,719
    08-07-2012, 08:53 AM Go to last post
  12. Sample size when comparing 3 groups (proportions)

    Problem: I use a common clinical specimen divided equally into two sets with each set to test 3 culture media for growth of a certain organism after...

    Started by tapyboy‎, 08-06-2012 03:48 AM
    3 groups, 3 proportions, comparing percentages, sample size
    • Replies: 0
    • Views: 363
    08-06-2012, 03:48 AM Go to last post
  13. Am I allowed to pool groups for GLM?

    Here is my problem: I am doing a stability study, for which I have several lots on different storage temperatures. In order to asses the...

    Started by gamadeus‎, 07-13-2012 12:43 PM
    • Replies: 3
    • Views: 522
    08-03-2012, 09:15 AM Go to last post
  14. Discrepencies between SPSS and SAS

    Does anyone know why there are differences in results when performing Kaplan Meier survival analysis tests in SPSS and SAS. The values do not match...

    Started by pauljj‎, 07-31-2012 08:46 AM
    difference, kaplan meier, sas, spss, survival analysis
    • Replies: 8
    • Views: 788
    08-02-2012, 03:28 PM Go to last post
  15. biostatistics - command to use for association of fiber intake and cancer

    hi everyone can you help me which test i should use ? purpose is to determine the association of intake of dietary-fiber (3 different types of...

    Started by floritta‎, 07-10-2012 04:58 AM
    • Replies: 1
    • Views: 396
    08-02-2012, 07:25 AM Go to last post
  16. Cox Proportional Hazards Regression

    Hi, I am hoping someone can help me with which model (frailty, strata or cluster) I should use for my data. I have paired data so I need to take...

    Started by MJ77‎, 07-23-2012 03:01 AM
    cox regression, paired data, survival analysis, time to event
    • Replies: 1
    • Views: 483
    08-02-2012, 07:25 AM Go to last post
  17. Summing Confidence Intervals?

    Hello, I have calculated mean concentrations of various environmental chemicals in a population. These chemicals fall into different classes...

    Started by AMac‎, 07-30-2012 03:58 PM
    confidence intervals, means
    • Replies: 2
    • Views: 601
    08-01-2012, 07:08 PM Go to last post
  18. Univariate or Multivariate?

    Hi My data is on two equal groups of patients. The two groups have roughly equal proportions of males/females. A blood sample was obtained form each...

    Started by ASSAN‎, 07-15-2012 12:49 PM
    blood tests, multivariate, non-parametric tests, npmanova, univariate
    • Replies: 2
    • Views: 511
    08-01-2012, 06:58 PM Go to last post
  19. Sample size calculations

    Hi all, I know nothing about sample size calculations, and always feel that this is an area I am lacking in. In general I work with data that has...

    Started by duskstar‎, 07-23-2012 09:04 AM
    • Replies: 5
    • Views: 522
    07-31-2012, 08:32 AM Go to last post
  20. MANOVAs

    Hi, I’ve performed a MANOVA but cannot perform a box test (because I have fewer subjects per factor than dependent variables). I was wondering if...

    Started by bs10cjg‎, 07-31-2012 06:25 AM
    manova
    • Replies: 0
    • Views: 283
    07-31-2012, 06:25 AM Go to last post
  21. Nested/Repeated Comparisons-What test should I use?

    Hi! I am having trouble to decide what statistical test to use on my data because I have one factor grouped within another. Here is my...

    Started by WhackyWolbachia‎, 07-10-2012 05:53 AM
    experimental design, microarray, multiple comparisons, nested analysis
    • Replies: 3
    • Views: 502
    07-30-2012, 10:45 AM Go to last post
  22. Characterizing a population

    Hello, I have data regarding some new blood test. I have a large sample of 450 patients, all healthy, and I would like to characterize the...

    Started by NN_STAT‎, 07-24-2012 04:06 AM
    • Replies: 6
    • Views: 689
    07-28-2012, 07:56 PM Go to last post
  23. Which test to use?

    Hi everyone, I'm working on analyzing some data right now but I'm not sure if I'm even approaching this correctly. I have a master set of data that I...

    Started by lembdan‎, 07-27-2012 08:56 AM
    • Replies: 0
    • Views: 326
    07-27-2012, 08:56 AM Go to last post
  24. How to compare paired, non-normal and GROUPED data?

    Hi, community, I'm trying to solve this issue using free software on Mac OS X and Ubuntu, namely PSPP (SPSS-compatible), Gnumeric, LibreOffice,...

    Started by Cubytus‎, 07-27-2012 01:44 AM
    • Replies: 0
    • Views: 306
    07-27-2012, 01:44 AM Go to last post
  25. How to compare repeated measurements

    Okay, I have one group of patients. This is a hypothetical example: drug A and B are drugs that decrease puls rate. After application of...

    Started by med1234‎, 06-23-2012 05:31 PM
    • Replies: 6
    • Views: 931
    07-16-2012, 10:15 PM Go to last post
  26. Variance used as dependent variable in logistic regression

    Hi all, I'm investigating the factors that contribute to high or low variability in the greenness index of a grassland area over the course of 10...

    Started by Walker‎, 07-10-2012 11:21 AM
    • Replies: 2
    • Views: 423
    07-12-2012, 04:50 PM Go to last post
  27. FDR and FWER

    Hello, I was looking for some online material about False Discovery Rate and Family wise Error Rate. I found a nice lecture that consisted of 2...

    Started by NN_STAT‎, 02-11-2012 08:20 AM
    • Replies: 5
    • Views: 4,241
    07-12-2012, 06:38 AM Go to last post
  28. Propensity Score Matching

    Hello, I have retrospective non-randomised data and wish to investigate the relationship between blood transfusions (2 treatment groups :...

    Started by macguilm‎, 07-09-2012 07:56 AM
    propensity score matching
    • Replies: 3
    • Views: 542
    07-09-2012, 09:04 AM Go to last post
  29. Understanding how PFS and other "survival" outcomes are actually defined

    Hello, I am trying to better understand how are end points in clinical trials defined when Kaplan-Meier method/log rank test is used. I met this...

    Started by Markica85‎, 07-05-2012 03:53 PM
    • Replies: 0
    • Views: 327
    07-05-2012, 03:53 PM Go to last post
  30. groups clustering

    Hello everybody, I was wondering about a method to lump a dataset of 20 groups of subjects, each group characterized by a specific mean age, stand...

    Started by marco77‎, 07-05-2012 12:29 PM
    • Replies: 0
    • Views: 331
    07-05-2012, 12:29 PM Go to last post
  31. test to evaluate paired data with 2 ind variables?

    Hello, I am conducting a basic preference test experiment to determine whether subjects spend a longer time investigating sample A vs. B, and for...

    Started by Els22‎, 07-02-2012 12:13 AM
    • Replies: 0
    • Views: 406
    07-02-2012, 12:13 AM Go to last post
  32. Impact of age and treatment approach on incidence rates of adverse outcome

    In a meta-analysis looking at the impact of age on the incidence of an adverse outcome following treatment for "X", which effect sizes and...

    Started by mhill6‎, 07-01-2012 01:21 AM
    • Replies: 0
    • Views: 310
    07-01-2012, 01:21 AM Go to last post
  33. Testing a drug's effect on survival across multiple distinct studies

    I have survival and other data for between ~1000 patients from different studies with indications varying from organ transplantation to cancer....

    Started by ieee529‎, 06-30-2012 09:26 AM
    • Replies: 0
    • Views: 375
    06-30-2012, 09:26 AM Go to last post
  34. SEM identifiability

    My question concerns a Structural Equations Modeling analysis. Should one be worried about a model being partially, over, or under identified after...

    Started by azalea‎, 06-21-2012 04:30 PM
    • Replies: 2
    • Views: 660
    06-28-2012, 05:41 PM Go to last post
  35. Normal distribution, do I have it?

    Hi. I've been writing here before and got some great answers. But the discussion became a bit too complicated/confusing, so I'm trying to go back...

    Started by Amana‎, 06-20-2012 03:54 AM
    • Replies: 5
    • Views: 791
    06-25-2012, 09:05 AM Go to last post
  36. Multiphase Survival Estimation - Data Modeling & Collinearity (Stata)

    Dear Forum Members and Statistics Ballers! I am currently trying to model a survival function for entrepreneurs, and would like to specifically...

    Started by Basti‎, 06-25-2012 04:12 AM
    interaction, multi, multiphase, phase, survival
    • Replies: 0
    • Views: 585
    06-25-2012, 04:12 AM Go to last post
  37. Question How can i calculate the sample size in this situation?

    I am designing a RCT between two interventions (two closure techniques of abdomen after an operation) to assess their safety, the safe intervention...

    Started by safwan‎, 06-23-2012 02:52 PM
    rct, sample size
    • Replies: 0
    • Views: 412
    06-23-2012, 02:52 PM Go to last post
  38. logistic regression

    In performing multivariate logistic regression with the WINKS software the output is given as a contingency table with predicted and actual outcomes...

    Started by bgaynes‎, 06-18-2012 12:50 PM
    • Replies: 2
    • Views: 633
    06-19-2012, 07:15 PM Go to last post
  39. Normality violations - still use ANOVA?

    Hi all, I am having some trouble deciding which test to run for a chapter of my thesis. The brief intro is that I felled trees, cut them into an...

    Started by jhartsho‎, 06-10-2012 04:43 PM
    • Replies: 2
    • Views: 778
    06-15-2012, 09:18 AM Go to last post
  40. Question Parametric test results vs Non-parametric test results - interpretation help please?

    :wave: Hello, thank you so much for your help. I am currently working on an article about trends in streamflow in watersheds with different land...

    Started by Olia‎, 06-09-2012 04:39 PM
    linear regression, mann-kendall, non-parametric, parametric, results
    • Replies: 1
    • Views: 724
    06-15-2012, 08:03 AM Go to last post
  41. Sensitivy/specificity - I'm confused

    Hi All, I'm thinking about Sens vs Spec, like in the worked example here: http://en.wikipedia.org/wiki/Sensitivity_and_specificity but there...

    Started by Bas van Dijk‎, 06-11-2012 04:45 AM
    • Replies: 6
    • Views: 835
    06-12-2012, 02:57 AM Go to last post
  42. Proper statistical test

    I am doing a very simple assay to determine if biofilms are reduced when treated with a compound. Every time I run the assay I run an untreated...

    Started by rudy‎, 06-01-2012 11:06 PM
    • Replies: 1
    • Views: 587
    06-10-2012, 05:01 PM Go to last post
  43. Question How to analyze significant within, nonsignificant between?

    Hi everyone, hopefully this is in the right forum. I ran a mixed between-within subjects ANOVA in SPSS to see whether habitat affected the change...

    Started by Ateguava‎, 06-08-2012 02:49 PM
    • Replies: 2
    • Views: 462
    06-09-2012, 12:18 PM Go to last post
  44. analysis using multiple complex surveys

    Hi, I've posted a couple times before - hadn't gotten replies but have kept plugging away. I thought I'd give it one more try with updated...

    Started by birdsong‎, 06-07-2012 10:08 AM
    • Replies: 0
    • Views: 467
    06-07-2012, 10:08 AM Go to last post
  45. Question [Anova using R] Likely need help setting up a multi way ANOVA, open to other options

    I am analyzing the data from an MRI experiment where we tested a new contrast agent against two control agents in mice with tumors. The experiment...

    Started by EAlexWaters‎, 06-05-2012 06:26 PM
    anova, biology, glm, mri
    • Replies: 0
    • Views: 384
    06-05-2012, 06:26 PM Go to last post
  46. Cox PH model results

    Hi all, When I run a simple Cox proportional hazards model with one categorical variable with 3 levels...1) No pulmonary hypertension, 2) Passive...

    Started by mostater‎, 06-05-2012 10:54 AM
    • Replies: 3
    • Views: 561
    06-05-2012, 02:28 PM Go to last post
  47. Exclamation Variance of a corrected regression coefficient

    Ppl I really need help! Please, help me solve it: Consider the model Yi = b0 + b 1Xi +ei e_i~N(0,s^2_e) iid X_i_N(m_x,s^2_x) iid Z_i = X_i +...

    Started by Arttemus‎, 06-04-2012 03:10 PM
    delta method, regression coefficient, reliability ratio
    • Replies: 0
    • Views: 348
    06-04-2012, 03:10 PM Go to last post
  48. 3 study areas - changes in incidence/prev over time within AND between study areas?

    Hi everyone, I just thought it's easiest if I go through my research plan and the aim to put things into context. I've been told one thing by one...

    Started by wernie‎, 06-01-2012 11:44 PM
    prevalence incidence
    • Replies: 0
    • Views: 479
    06-01-2012, 11:44 PM Go to last post
  49. diagnostic testing and sample size calculation

    Hello everyone, I did a study evaluating 2 screening tools (questionnaires) compared to a reference in the same sample of patients. So all the...

    Started by noob‎, 05-19-2012 03:17 PM
    • Replies: 4
    • Views: 2,421
    05-31-2012, 06:22 PM Go to last post
  50. using chi square test with data having uncertainties

    Hello, I am interested in comparing proportions between two populations. For example, let's say in one box of 100 marbles there are 20 blues,...

    Started by birdsong‎, 05-30-2012 11:12 AM
    • Replies: 0
    • Views: 512
    05-30-2012, 11:12 AM Go to last post
  51. Question Nonparametrics, which test should I use?

    Hello. I am a veterinary student who is stuck in some statistics. I am doing an experiment with mice. I have two treatment groups and have...

    Started by Amana‎, 05-11-2012 08:12 AM
    3 Pages
    1 2 3
    • Replies: 30
    • Views: 2,344
    05-30-2012, 09:12 AM Go to last post
  52. NAMCS, NHAMCS and SPSS

    Hello, I am analyzing NAMC and NHAMCS ambulatory health care survey data using SPSS. There are design variables in the data files that can be...

    Started by birdsong‎, 05-26-2012 05:45 PM
    • Replies: 0
    • Views: 551
    05-26-2012, 05:45 PM Go to last post
  53. Sample size calculation for a cluster small sample

    I am planning an evaluation of a health program that is being implemented at 42 health facilities. I will do a quasi experimental study that will be...

    Started by ozayr411‎, 05-24-2012 01:20 PM
    • Replies: 0
    • Views: 522
    05-24-2012, 01:20 PM Go to last post
  54. Identifying Unusual Cases in SPSS 20

    Hi, I am exploring SPSS 20 and there is this new option which seems promising: Anomaly Indices, it is in Data>Identify Unusual Cases. To me it seems...

    Started by mousme‎, 05-23-2012 05:29 AM
    • Replies: 0
    • Views: 820
    05-23-2012, 05:29 AM Go to last post
  55. Linear Regression question

    Dear All I am planning to perform a linear regression analysis to determine the predictor variables that best predict shallowing of the front...

    Started by SiBorg‎, 03-12-2012 01:27 PM
    • Replies: 5
    • Views: 1,254
    05-22-2012, 09:39 AM Go to last post
  56. Multivariate summary for interaction test

    Hi there, I'm trying to find some way to summarize multivariate data so that I can look at interaction terms for entire groups of molecules...

    Started by jmr‎, 05-22-2012 08:08 AM
    • Replies: 0
    • Views: 508
    05-22-2012, 08:08 AM Go to last post
  57. Linear Mixed Model.

    Hello, I have a question. What would be more appropriate when modeling repeated measure experiment depending from 2 groups Y~1+GROUP|ID, labels...

    Started by Mikhail‎, 05-22-2012 07:37 AM
    • Replies: 0
    • Views: 436
    05-22-2012, 07:37 AM Go to last post
  58. Breakpoints in multivariate analysis: GLM or regression splines

    Hello all, I've been breaking my head over the following problem for some time now, but have been unable to solve it. I'm trying to asses the...

    Started by Abubakar‎, 05-21-2012 03:49 PM
    • Replies: 0
    • Views: 513
    05-21-2012, 03:49 PM Go to last post
  59. Help! Awkward hypothesis testing

    Hello, I desperately need some help with my project... If someone could help me, I would be very very grateful! I am comparing the different...

    Started by 87che87‎, 05-20-2012 05:51 PM
    • Replies: 1
    • Views: 593
    05-20-2012, 06:10 PM Go to last post
  60. help with ROC curve analysis

    Hi there, I know this is my first post, but tried looking on the forum and couldn't find a specific answer to my question. I'm using SPSS 17 to...

    Started by LightsEternity‎, 05-15-2012 10:58 PM
    • Replies: 2
    • Views: 1,421
    05-20-2012, 05:02 AM Go to last post

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