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# Forum: Biostatistics

Epidemiology and biostatistics, public health research. GLM, logistic regression, survival analysis, clinical trials.

1. ### Nonparametric data analysis

I'm asking for advice. Topic of my research is brain iron accumulation. My task is the next . I have one dependent variable that is cathegorical and...

• Replies: 19
• Views: 293
Yesterday, 04:25 PM
2. ### evaluating performance

Hi all: We've run up against a bit of a difficult scenario and we're looking for input on how to proceed. I will give some background on our data...

• Replies: 3
• Views: 97
Yesterday, 10:27 AM
3. ### Question about meta-analysis

Hello! I'm new here and I'm not a statistician but I would appreciate your inputs. Is it possible to make a meta-analysis investigating results...

• Replies: 8
• Views: 284
11-10-2017, 10:33 AM
4. ### Statistical test for annual crude mortality trend (3 years data=3 data points)

Help, I have the crude mortality figures for 2015, 2016, 2017 and would like to know if the figure for 2017 is statistically different. The...

• Replies: 1
• Views: 104
11-09-2017, 07:15 AM
5. ### What statistical test should I use?

Hello, I am currently working on my thesis proposal and am having to state the proposed methods of my data analysis. I am focusing on two aims: 1)...

• Replies: 1
• Views: 171
11-07-2017, 02:42 AM
6. ### P-Trend, what does it mean and how being calculated?

Hello all :) I need your help... I am trying to make analysis based on a similar paper, and I can't understand the statistical method to be...

• Replies: 0
• Views: 226
10-28-2017, 12:29 PM
7. ### [SPSS - Mixed Models] Repeated measurements data from randomised controlled trial

I am analyzing data from a randomized clinical trial, with 2 intervention groups (placebo and intervention) and repeated measurements over time. I am...

• Replies: 3
• Views: 344
10-22-2017, 05:59 AM
8. ### Means are not different but significant

Hi. I have a query, generated from PrediXcan analysis but more related to statistics. I have the two means of predicted expression values for...

• Replies: 1
• Views: 353
10-20-2017, 08:35 AM
9. ### Multiple t-tests vs ANOVA with Dunnett's post-hoc test

Hello, I am bit confused about the use of multiple t-tests vs ANOVA with Dunnett's post-hoc test (on normally distributed data). Let's take the...

• Replies: 2
• Views: 298
10-14-2017, 12:18 PM
10. ### Retrospective chart review subject selection: case vs. control

I did retrospective chart review on 240 subjects from my previous institute. THe study was on sedation required for bronchoscopy. The procedure used...

• Replies: 0
• Views: 149
10-14-2017, 10:37 AM
11. ### RCT: estimation of total sample size knowing only the percentage of occurrence

Dear all, I was asked to estimate the minimum sample size to set up a RCT comparing a standard dose technique to detect recurrence of disease vs...

• Replies: 0
• Views: 136
10-12-2017, 04:31 AM
12. ### Triangulating multiple data sources of prescription information

I am currently working on a retrospective database study assessing the real-world effectiveness of a medication. I am faced with a few challenges. I...

• Replies: 0
• Views: 192
10-06-2017, 11:59 AM
13. ### Comparing the effectiveness of an intervention in two groups?

Hi Everyone, I'm stuck trying to find a way to compare whether or not a given intervention has a greater effect in one group (Kids < 5) than...

• Replies: 1
• Views: 171
10-04-2017, 08:01 AM
14. ### Block design anova

I have a question about what the most appropriate anova design is for my data. I am posting here because I cannot seem to get the search function to...

• Replies: 2
• Views: 434
09-29-2017, 08:35 AM
15. ### Using logistic regression to compute age-adjusted rates

Dear All, Would anybody please give me a breakdown no how to compute "age-adjusted proportions" based on the logistic regression coefficients? ...

• Replies: 4
• Views: 587
09-22-2017, 10:02 AM
16. ### Interpreting significance based on confidence interval

Hi Everyone, Could some of you help to interpret my results based on p values and confidence intervals? A little bit of background: I am trying to...

• Replies: 3
• Views: 328
09-22-2017, 05:04 AM
17. ### Repeated measures with varying count between group

I'll explain my problem a bit: I have two groups S(story) and P(picture). Each is composed of the same 48 subjects. My endpoint is a 'score' on an...

• Replies: 5
• Views: 445
09-20-2017, 05:05 PM
18. ### Modeling and predicting pathology from multivariate clinical data

Hello, I have a clinical data set that consists of 5 clinical measurements on thousands of tissue samples. Furthermore, each sample has a pathology...

• Replies: 2
• Views: 252
09-11-2017, 09:55 AM
19. ### what statistical test to choose (large smple size)

Hi all, I need to perform a test which shows if there is a statistical difference between males and females in getting diagnosis. I believe I should...

• Replies: 2
• Views: 322
09-10-2017, 09:48 AM
20. ### Chi square p value <0.01 but graph pad prompts not valid

Hello all, i have used graph pad prism to calculate p- value. my contingency table contains some observed frequencies which are 0. my p-value has...

• Replies: 1
• Views: 218
09-09-2017, 01:09 PM
21. ### Poll: Similarity instead of differences in means b/w 2 groups

Hi - long time lurker. First time poster. I'm hoping folks can provide guidance and opinions. I am looking at a small pilot study (n=16) of...

• Replies: 4
• Views: 595
08-28-2017, 03:33 PM
22. ### Is Chi-square appropriate for a single measurement variable with repeated measures?

Hi! I am looking at how many burrows are occupied by a skink species at eight sites across a property. Counts of the number of occupied burrows...

• Replies: 2
• Views: 373
08-24-2017, 06:20 PM
23. ### One way ANOVA vs Kruskal Wallis

Hi, I am comparing four groups (measurements of bone thickness and other bone parameters). The distributions are normal (Kolmogorov–Smirnov test)...

• Replies: 1
• Views: 464
08-23-2017, 08:38 AM
24. ### Can I calculate the % of people positive for an outcome from an odds ratio?

Hi, Thanks for looking at my question. Background I am doing a systematic reveiw and metanalysis, essentially on diagnostic test accuracy and...

• Replies: 8
• Views: 436
08-21-2017, 02:45 AM
25. ### Cox Regression with missing values

Very grateful for any advice. I'm trying to perform Cox regression on a data set with multiple random missing values. SPSS is my go-to software,...

• Replies: 5
• Views: 562
08-17-2017, 05:06 AM
26. ### Best scenario: unpaired or paired situation?

I have a few questions, but first let me give you some necessary background of the experiment and the underlying questions. Basically, the design...

• Replies: 0
• Views: 356
08-15-2017, 11:37 AM
27. ### Freidman test with missing values?

I have a set of data at four time points, but some subjects only two out of the four time points. Can I still use Friedman test for this in SPSS?

• Replies: 0
• Views: 198
zhu
08-15-2017, 11:34 AM
28. ### Propensity Score Matching

Hi! I'm conducting a retrospective study in which we want to analyze time period of 60 days before occurence of a particular adverse event. To do...

• Replies: 1
• Views: 444
08-09-2017, 08:56 AM
29. ### Poisson Standard Deviation

Hi! Just a sanity check as I have to do a few computations for a report manually. Our indicator is defined in the following way: #...

• Replies: 6
• Views: 1,064
08-08-2017, 09:34 PM
30. ### Normal Approximation, Fisher's Exact Test, Relative Risk or Odds Ratio?

A clinical trial is being planned, in which the primary outcome is binary (success/failure). There are two treatment groups (treatment/control). The...

• Replies: 7
• Views: 965
08-08-2017, 09:33 PM
31. ### Help with correct statistical analysis?

I am conducting an audit into vitamin D deficiency in children. I have the mean serum concentrations of vitamin D in specific areas (postcodes)...

• Replies: 5
• Views: 811
08-08-2017, 09:32 PM
32. ### Critiquing a Network Meta-analysis: Interpreting inconsistency

Hi all. I'm a non-statistician trying to critique a network meta-analysis on a group of migraine medications called triptans (PDF link). The...

• Replies: 3
• Views: 438
08-08-2017, 09:30 PM
33. ### STATA Logistic Regression Intepretation

Hi, My dependent variable is goes to college coded 0=No and 1= Yes. I am not sure how STATA reads/ranks the dependent variable....thus I am not...

• Replies: 0
• Views: 397
08-03-2017, 02:53 PM
34. ### Sphericity with unequal sample sizes

Hello, I want to do a repeated measures anova in R on a data set consisting of four treatments on subjects, over 4 weeks. However, in week 3 I am...

• Replies: 0
• Views: 392
07-30-2017, 11:21 AM
35. ### Need Appropriate Test for comparing a series of measurements from one bone to another

My research involves taking measurements at 9 sections at different locations on the shaft of bones. I am having trouble determining which...

• Replies: 2
• Views: 582
07-23-2017, 08:41 PM
36. ### Online Biostatistics Course/Master's Degree

Hi everyone, I'll be glad if someone could recommend me some online Biostatistics Course or Master's Degree for beginner. Thanks!

• Replies: 1
• Views: 661
07-20-2017, 04:23 AM
37. ### Patient-year Incidence rates comparisons and p value

Dear all, I would like to statistically compare two incidence rates from two different groupes. I found the Incidence rate difference (IRD)...

• Replies: 0
• Views: 409
07-19-2017, 04:43 AM
38. ### Help with comparing disease death rates over time

Hello everyone, I am working with a national mortality file and have pulled certain deaths for a particular disease and created crude rates by...

• Replies: 0
• Views: 1,240
07-17-2017, 07:03 PM
39. ### Software for NHANES Analysis

Hello! I'm going to be using NHANES data for some of my research looking at dietary factors and health-related outcomes. I have a bit of exposure to...

• Replies: 0
• Views: 478
07-14-2017, 04:25 PM
40. ### Multi-level Meta-regression using random effect for treatment? [R pkg metafor]

I am a biostatistician consulting on a meta-analysis of 16 studies each w/ 2 treatment arms. The main interest is in the effect of the variable...

• Replies: 0
• Views: 507
07-06-2017, 03:45 AM
41. ### Help choosing right statistics

The experiment consisted of testing the effect of several diets on the weight of fish. I want to check what groups differ from each other. There is...

• Replies: 2
• Views: 711
06-26-2017, 04:06 PM
42. ### sample size calculation for chi square test with more than 2 groups

Greetings everybody I'm running a sample size estimation for a study that will use chi square test of association for the qualitative comparison of...

• Replies: 4
• Views: 1,372
06-08-2017, 10:58 AM
43. ### test for cumulative analysis of outcomes over time in meta-analysis

A systematic review and meta-analysis I am reading references having tested for chronological cumulative analysis for the effects of the outcomes...

• Replies: 3
• Views: 1,281
06-04-2017, 03:02 PM
44. ### Simple question re retrospective study types

Hi, Please could someone confirm that I'm using the correct terminology to describe two studies listed below. I think that they are both...

• Replies: 2
• Views: 1,709
05-30-2017, 03:48 PM
45. ### Non Inferiority with a Historical Control

Is it possible or valid to do a Non-Inferioirty Test againts a historical control. I should point out for the historical control all I have is a...

• Replies: 1
• Views: 980
05-30-2017, 08:46 AM
46. ### Should I perform a PCA on my datas?

Hi, I'm new to the statistic world. I have doubts about pca. I am performing the statistics of my study and I have a lot of data. I wonder if I can...

• Replies: 0
• Views: 991
05-26-2017, 08:36 AM
47. ### covariate for only clinical group

HI I have tried to find an answer on the web but was not able, and will appreciate your help! I have a question regarding the use of a covariate in...

• Replies: 3
• Views: 1,544
05-22-2017, 09:28 AM
48. ### Absolute values or Log-transformed data

I want to perform a non parametric test (mann-whitney) for my experiments that is briefly quantification of viral load (Real Time Polymerase chain...

• Replies: 3
• Views: 1,258
05-15-2017, 08:55 PM
49. ### Is Cochran's Q the right test for repeated measures with binary outcomes?

Hi, I am trying to analyze a data set. The question we are looking at is whether the rate of a successful outcome and the risk of a...

• Replies: 0
• Views: 933
05-12-2017, 12:15 PM
50. ### GLM with non-linear predictor

Hi, I am analyzing a dataset looking at procedural skill development. The data itself is binomial, whether or not a procedure was successful. When...

• Replies: 0
• Views: 924
05-06-2017, 11:02 PM
51. ### Contingency tables with proportions only

Hi, I have a 3x2 contingency table, which contains the observed and expected allele frequencies from a hypothetical population and I'd like to test...

• Replies: 8
• Views: 2,042
05-04-2017, 05:59 PM
52. ### Chi-square goodness of fit test

Hi all, I'm currently conducting research at a radiology department. The setup of our research is that we let 2 radiologists indicate their...

• Replies: 1
• Views: 1,160
05-01-2017, 04:23 AM
53. ### Association/ correlation binary and continuous data non-normal distribution

Hi, I want to perform an association analysis between a binary (dichotomous?) variable and continuous variable. The binary variable is whether...

• Replies: 5
• Views: 1,208
04-27-2017, 02:59 PM

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