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Forum: Biostatistics

Epidemiology and biostatistics, public health research. GLM, logistic regression, survival analysis, clinical trials.

  1. covariate for only clinical group

    HI I have tried to find an answer on the web but was not able, and will appreciate your help! I have a question regarding the use of a covariate in...

    Started by newbeeme‎, 05-21-2017 01:48 AM
    • Replies: 3
    • Views: 251
    05-22-2017, 09:28 AM Go to last post
  2. Absolute values or Log-transformed data

    I want to perform a non parametric test (mann-whitney) for my experiments that is briefly quantification of viral load (Real Time Polymerase chain...

    Started by julian_DE‎, 05-15-2017 01:06 AM
    • Replies: 3
    • Views: 305
    05-15-2017, 08:55 PM Go to last post
  3. Smile Mixed Model Analysis SPSS

    Hello All, I have a data set which I am trying to find out what is the best way to go about analyzing. I have been asking around and was advised...

    Started by quix09‎, 05-15-2017 08:24 AM
    • Replies: 0
    • Views: 124
    05-15-2017, 08:24 AM Go to last post
  4. Is Cochran's Q the right test for repeated measures with binary outcomes?

    Hi, I am trying to analyze a data set. The question we are looking at is whether the rate of a successful outcome and the risk of a...

    Started by Jennifer Kosty‎, 05-12-2017 12:15 PM
    • Replies: 0
    • Views: 154
    05-12-2017, 12:15 PM Go to last post
  5. Different proportions in different conditions?

    Hi, I am struggling with the proper way to analyze my data. I did some research in and out of this forum but could not find the answer to my...

    Started by Fanny-‎, 04-11-2017 08:06 AM
    • Replies: 3
    • Views: 533
    05-07-2017, 03:06 AM Go to last post
  6. GLM with non-linear predictor

    Hi, I am analyzing a dataset looking at procedural skill development. The data itself is binomial, whether or not a procedure was successful. When...

    Started by amw2320‎, 05-06-2017 11:02 PM
    • Replies: 0
    • Views: 187
    05-06-2017, 11:02 PM Go to last post
  7. Contingency tables with proportions only

    Hi, I have a 3x2 contingency table, which contains the observed and expected allele frequencies from a hypothetical population and I'd like to test...

    Started by Acather96‎, 05-04-2017 02:23 PM
    • Replies: 8
    • Views: 349
    05-04-2017, 05:59 PM Go to last post
  8. Post Chi-square goodness of fit test

    Hi all, I'm currently conducting research at a radiology department. The setup of our research is that we let 2 radiologists indicate their...

    Started by MaxTalksStats‎, 05-01-2017 03:29 AM
    • Replies: 1
    • Views: 289
    05-01-2017, 04:23 AM Go to last post
  9. Association/ correlation binary and continuous data non-normal distribution

    Hi, I want to perform an association analysis between a binary (dichotomous?) variable and continuous variable. The binary variable is whether...

    Started by Hannah212‎, 04-27-2017 03:37 AM
    binary, continuous, correlation analysis, point-biserial
    • Replies: 5
    • Views: 326
    04-27-2017, 02:59 PM Go to last post
  10. Wink Antibiogram

    greetings :yup: im doing a documentary review of the Clinical Profile and Antibiogram Pattern of Patients With Diabetic Foot Ulcers. Problem is, I...

    Started by otepmeimban‎, 04-27-2017 12:44 PM
    • Replies: 1
    • Views: 177
    04-27-2017, 01:02 PM Go to last post
  11. what statistical test to choose

    Hi all, I am working on a similar kind of project as this https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313376/ For table 2, what are the...

    Started by bburugap‎, 04-24-2017 02:15 PM
    • Replies: 0
    • Views: 251
    04-24-2017, 02:15 PM Go to last post
  12. Can i use one sample t-test?

    Hi all Currently im doing a research to see how effective my results as compared to the mean value and standard deviation of previous study. ...

    Started by hnw‎, 04-20-2017 04:41 AM
    one sample t test
    • Replies: 2
    • Views: 347
    04-20-2017, 08:16 AM Go to last post
  13. Question reference interval determination

    Hi all, I was wondering if I could ask for some help from some more statistically inclined persons than myself. We are trying to determine a...

    Started by romes‎, 03-25-2017 10:23 AM
    biostatistics, reference interval
    • Replies: 1
    • Views: 477
    04-16-2017, 08:32 AM Go to last post
  14. Problem with normalization and - proteomics analysis (LC-MS)

    Hi folks, I am working with proteomics data, containing mainly LC-MS and NMRI analysis. Firstly, I must normalise data to give valuable compound...

    Started by robertp‎, 04-15-2017 11:04 AM
    biostatistics, data analysis, nmri, normalization, proteomics
    • Replies: 0
    • Views: 164
    04-15-2017, 11:04 AM Go to last post
  15. Bias Question

    My statistics teacher and I are at a disagreement with an answer to one of his questions and I was wondering if you all could help me out. The...

    Started by jimsam321‎, 04-12-2017 04:55 PM
    • Replies: 14
    • Views: 433
    04-13-2017, 09:29 AM Go to last post
  16. Question Comparing groups - Should I do hypotesis testing on raw counts or percentage values?

    Hi, first post here, and I really hope you can help me with this. I'm measuring the number of cells labelled with two markers (let's call them A...

    Started by sgomes‎, 04-10-2017 10:37 AM
    • Replies: 3
    • Views: 333
    04-10-2017, 04:57 PM Go to last post
  17. Chi Square test (not significant when comparing across 4 groups but changes with 2)

    Hi all, I was conducting a chi-square + fisher test and ran across a problem: I am using a chi square to test whether or not there is an...

    Started by Nives_ES‎, 04-07-2017 11:45 AM
    • Replies: 2
    • Views: 366
    04-07-2017, 02:08 PM Go to last post
  18. Statistical help (not independent samples)

    Hello all, I need some help in understanding what statistical test to use when I have 3 groups and the groups are not independent of each other...

    Started by bburugap‎, 04-01-2017 02:40 PM
    • Replies: 2
    • Views: 404
    04-05-2017, 04:04 PM Go to last post
  19. How to do age standardization for morbidity study (2 populations)

    Good day all, I have a question in regards to age standardization. My study is on morbidity(disease) and I have 2 populations. The populations are...

    Started by happiness17‎, 04-04-2017 04:47 AM
    • Replies: 0
    • Views: 244
    04-04-2017, 04:47 AM Go to last post
  20. Unhappy Which test for equivalency?

    I have two machines A & B. 5 patients. I calculate the elasticity of their skin with the two different machines. This gives me two numbers per...

    Started by yolo123‎, 04-01-2017 07:00 PM
    • Replies: 6
    • Views: 478
    04-02-2017, 04:15 PM Go to last post
  21. PCA questions?

    Hi there, I am a bit new to statistics and have a few questions. I am currently doing my dissertation on the consistent and variable...

    Started by Callum94‎, 03-29-2017 12:59 PM
    • Replies: 3
    • Views: 534
    03-29-2017, 06:36 PM Go to last post
  22. Predicting outcome with multiple groups

    Hi everyone, I'm currently working with 3 different groups (3 disease populations) and I would like to predict which of the three groups they fall...

    Started by Eric2014‎, 03-28-2017 12:14 PM
    groups, logistic, prediction, regression
    • Replies: 4
    • Views: 402
    03-28-2017, 03:45 PM Go to last post
  23. Finding data given sample mean and variance

    Hello, I have a problem, I am given the sample size, mean, variance, and I know it is normally distributed. The question states that 160...

    Started by dorothy8‎, 03-26-2017 06:56 PM
    • Replies: 2
    • Views: 337
    03-27-2017, 09:56 PM Go to last post
  24. am i overadjusting?

    might sound silly but for my research topic I am looking into insulin resistance (IR) and dietary factors. We are measuring IR by the use of...

    Started by jkerr1‎, 03-27-2017 04:56 AM
    • Replies: 1
    • Views: 338
    03-27-2017, 10:23 AM Go to last post
  25. Confidence interval question

    Fr a sample of 100 hypertensive patients, we find that a 95% confidence interval of systolic BP to be . What statement is FALSE? A- if a drug is...

    Started by dorothy8‎, 03-26-2017 05:53 PM
    • Replies: 1
    • Views: 289
    03-27-2017, 02:20 AM Go to last post
  26. Pre and post comparison for nonparametric unpaired sample

    Hi. I am not sure how to compare the results from the following study. Number of wrong orders out of total orders placed every day for 60 days as...

    Started by anupamsule‎, 03-22-2017 09:01 PM
    • Replies: 2
    • Views: 545
    03-24-2017, 07:04 AM Go to last post
  27. Dealing with Log(0)

    Dear all, Iíve been stuck for quite some time with a problem that relates to use of log-scale with values that equal zero. My data comes from an...

    Started by ritmaniac‎, 03-21-2017 07:21 AM
    anova, linear regression, logarithmic
    • Replies: 2
    • Views: 485
    03-21-2017, 04:22 PM Go to last post
  28. Sample size calculation for 1:2 matched case-control study

    Hi, I have a matched case-control study with 12 cases and two controls for each case. Evaluating our findings, I want to calculate what our sample...

    Started by teapot‎, 03-08-2017 02:22 PM
    • Replies: 7
    • Views: 994
    03-17-2017, 08:59 AM Go to last post
  29. stratified log-rank test and proportional hazards

    Does stratified log-rank test overcome problem of violation of proportional hazards? I encountered a randomized controlled study of a new drug...

    Started by Markica85‎, 03-16-2017 04:53 AM
    • Replies: 0
    • Views: 434
    03-16-2017, 04:53 AM Go to last post
  30. Regarding Maximum Percent different

    Dear all, Could you please explain what maximum percent different for continues vital DiaBP data. How to calculate this? Could you any one...

    Started by Statvijay‎, 03-14-2017 07:08 AM
    • Replies: 0
    • Views: 362
    03-14-2017, 07:08 AM Go to last post
  31. Survival Analysis - Time to utilization of medical services

    Hi all, I work in the medical field and Iím looking into using survival analysis calculate time to utilization of medical services, that is, once...

    Started by avbraga‎, 03-10-2017 04:35 PM
    • Replies: 6
    • Views: 550
    03-13-2017, 06:07 PM Go to last post
  32. vision in eyes at different times

    Hi everyone, New to the forum and am seeking a bit of guidance as to how to compare vision (visual acuity) between eyes. So I am trying to...

    Started by jksgoh‎, 03-11-2017 02:44 AM
    • Replies: 1
    • Views: 418
    03-13-2017, 02:42 PM Go to last post
  33. Which statistical tests are appropriate: Group means before and after treatment

    I am trying to find out what statistical tests to run on a set of aggregate data (no individual data) on 3 different groups, variables are summarized...

    Started by PamelaF‎, 03-07-2017 04:17 AM
    • Replies: 1
    • Views: 656
    03-09-2017, 04:31 PM Go to last post
  34. Adjustment for correlated data in meta-anlaysis

    Hi, I'm completing a systematic review and performing meta-anlaysis forest plots. The research question related to the finding of risk factors for...

    Started by Ainslie‎, 03-08-2017 12:47 AM
    adjustment, correlated data, meta-analysis
    • Replies: 2
    • Views: 603
    03-08-2017, 11:07 AM Go to last post
  35. standard deviation greater than variance, is this ok?

    I am putting together some audit results and it was suggested I present them as mean +/- SD. However there is a significant variance in the results....

    Started by Roundtoit‎, 03-07-2017 05:44 PM
    • Replies: 7
    • Views: 844
    03-08-2017, 04:23 AM Go to last post
  36. Comparing diagnostic tests - graphically demonstration

    Hi, This is very basic but really struggling to find the correct terminology to find out what I want to do. I have collected data on two methods...

    Started by k093‎, 03-07-2017 07:17 PM
    • Replies: 0
    • Views: 404
    03-07-2017, 07:17 PM Go to last post
  37. interpretation of a negative risk difference

    Hi, I am reviewing a cohort study and trying to make sense of the results. When considering mortality they presented their results as a risk...

    Started by Roundtoit‎, 03-05-2017 03:10 PM
    biostatistics, cohort study, risk difference
    • Replies: 1
    • Views: 666
    03-05-2017, 04:02 PM Go to last post
  38. Correct application of multiple testing methods in projects with several experiments

    Hi! I have a problem with evaluating how I should correct my alpha and conduct statistical texts when I have several different exeriments in the...

    Started by Szkeptik‎, 02-23-2017 04:32 AM
    anova, holm-bonferroni method, multiple testing
    • Replies: 1
    • Views: 694
    03-04-2017, 10:36 PM Go to last post
  39. Smile Comparative study

    Im doing comparative study of Kidney disease and Dermatoglyphics. There is a Continuous variable (ridge count) i am assessing Confounding factors is...

    Started by buddhikatbw‎, 03-03-2017 09:24 AM
    case control study
    • Replies: 2
    • Views: 531
    03-03-2017, 09:36 PM Go to last post
  40. matched pre-post survey analysis help

    I have matched pre-and post test data that evaluated our workshop participants using Likert-type items. Meaning, the same people were given the same...

    Started by hipstats‎, 02-28-2017 05:10 PM
    • Replies: 3
    • Views: 605
    03-03-2017, 08:52 AM Go to last post
  41. Test negative factors among correlated determinants

    Dear all, I am working on the obesity research. I found a molecule A that is negatively control the generation of adipocytes. I have a cohort of...

    Started by pinetop‎, 02-25-2017 12:05 AM
    correlation, negative, regression
    • Replies: 1
    • Views: 583
    03-02-2017, 01:41 PM Go to last post
  42. Cox regression to adjust for site effect in multicenter trial

    Hello All, Can stratified Cox regression be used to adjust for site effect in multicenter trials? Thank you in advance to all those who reply.

    Started by ineedhelpplease‎, 02-27-2017 10:44 PM
    • Replies: 3
    • Views: 938
    02-28-2017, 05:34 PM Go to last post
  43. Testing for trend

    I have following data that represent number of new patients with rare disease for subsequent 5 year time periods: 4, 3, 4, 2, 4, 2, 4, 6, 11 As I...

    Started by Markica85‎, 02-25-2017 09:25 AM
    • Replies: 12
    • Views: 1,294
    02-28-2017, 01:30 PM Go to last post
  44. Analysis of Repeated Measures Study with Unequal Time Between Measurements

    Hello Everyone, I have inherited the analysis of a study from a previous research student. I am having trouble determining what type of analysis...

    Started by rafreakijones‎, 02-10-2017 12:42 PM
    • Replies: 1
    • Views: 597
    02-24-2017, 09:56 PM Go to last post
  45. Statistical method to compare two experiments

    I have two data from biological experiment where two types of cells were measured. For each cell the data about composition of the membrane where...

    Started by magruc‎, 02-22-2017 04:23 AM
    • Replies: 1
    • Views: 565
    02-24-2017, 04:04 PM Go to last post
  46. Moran's I Spatial Autocorrelation. Interpreting results.

    I have carried out a Moran's I test on the residuals of a GLM model in the "ape" package in R which has returned the output below: Observed:...

    Started by avocadorose‎, 02-22-2017 02:16 PM
    glm, interpretation, spatial autocorrelation
    • Replies: 1
    • Views: 630
    02-23-2017, 06:40 AM Go to last post
  47. ADjusting for variables in regression model

    Dear all, I'm comparing two populations of oncologic patients that were treated with two different regimens in two different hospitals, group A of...

    Started by Markica85‎, 02-13-2017 06:43 AM
    • Replies: 6
    • Views: 1,022
    02-22-2017, 01:56 PM Go to last post
  48. Can I combine univariate and multivariate HR?

    Hi guys. I'm doing a meta-analysis of survival based on a blood marker, and not all the studies have provided a multivariate hazard ratio. Some have...

    Started by ngmowbray‎, 02-21-2017 07:38 AM
    medical statistics, meta analysis
    • Replies: 6
    • Views: 639
    02-21-2017, 09:08 PM Go to last post
  49. Categorical Variable with Repeated Data Points

    Hello, I have some data (continuous DV, nominal IV), that I would like to run an ANOVA or regression on. Strictly speaking, I have 3 levels, but...

    Started by StatsN00bie‎, 02-15-2017 03:22 PM
    • Replies: 1
    • Views: 742
    02-15-2017, 05:40 PM Go to last post
  50. Clinical decision interval

    Hi all, I have a question regarding clinical decision intervals (grey zone). We have developed a new screening test and we want to provide the...

    Started by Vbogaert‎, 02-08-2017 02:41 AM
    • Replies: 1
    • Views: 568
    02-13-2017, 08:24 AM Go to last post
  51. Assessing covariates to include in model

    Hi all, I have a couple of basic questions which would be great to get some help on I have a continuous outcome (brain volume: total and divided...

    Started by Alanine‎, 02-09-2017 10:47 AM
    • Replies: 2
    • Views: 654
    02-10-2017, 06:57 AM Go to last post
  52. Question [RNA-Seq] Sparse (discrete) p values with Cuffdiff

    Hello biostatisticians, I have run a very standard RNA-Seq protocol using TopHat - Cufflinks - Cuffmerge and Cuffdiff to measure differential gene...

    Started by FR_myologist‎, 02-08-2017 02:49 PM
    • Replies: 0
    • Views: 706
    02-08-2017, 02:49 PM Go to last post
  53. propensity matching and ITT for cohort study

    I am reviewing a cohort study that used a retrospective database to determine if treatment with hypothermia post cardiac arrest improves survival to...

    Started by Roundtoit‎, 02-06-2017 04:49 PM
    itt, propensity score matching, sensitivity analysis, survival analysis
    • Replies: 0
    • Views: 708
    02-06-2017, 04:49 PM Go to last post
  54. fixed vs mixed random effects model

    greetings, I am reviewing some meta-analysis and have a question regarding fixed vs random effects models. 2 reviews have used basically the same...

    Started by Roundtoit‎, 02-05-2017 08:12 PM
    • Replies: 4
    • Views: 1,021
    02-06-2017, 04:45 PM Go to last post
  55. Compensate for correlated observations

    Dear users I have an issue that I am not to solve alone and I am here to ask for your help. I work in the ophthalmology field and I have a group of...

    Started by rabiolo.alessandro‎, 01-30-2017 07:09 PM
    • Replies: 4
    • Views: 1,354
    02-01-2017, 03:28 PM Go to last post
  56. Proper analysis method for dataset involving multiple sessions

    I have a dataset that was collected over 5 discrete sessions, with each session collected on a different date. During each session, 10 human subjects...

    Started by statsSeeker‎, 01-31-2017 03:01 PM
    multiple sessions
    • Replies: 0
    • Views: 639
    01-31-2017, 03:01 PM Go to last post
  57. Ratio between control and treatment siginificantly different than 1

    I would like to know what kind of test I can use to verify my findings. In general I have a two group of people. One is a control group the other one...

    Started by Shaxi Liver‎, 01-26-2017 10:10 AM
    • Replies: 2
    • Views: 1,221
    01-27-2017, 04:43 PM Go to last post
  58. Equivalence test or non inferiority test for non parametric data using stata or spss

    I am doing a retrospective study about a new medical device, comparing it with an older device. the first group has 18 cases and the other group has...

    Started by drAmrBadawy‎, 01-25-2017 09:25 PM
    • Replies: 4
    • Views: 1,473
    01-26-2017, 12:08 AM Go to last post
  59. McNemar or Chi sqared test for case-control study

    Dear all, I'm facing a dilemma which test would be appropriate to compare frequency of a feature in two age, sex and...

    Started by Markica85‎, 01-20-2017 06:59 AM
    • Replies: 5
    • Views: 1,686
    01-25-2017, 02:57 PM Go to last post
  60. Issues with ANOVA and bounded variables (percentages)

    Hey all, Iím new here. I have an issue with a percentages and the use of ANOVA. But letís start from the beginning. I m a PhD Student and I study...

    Started by MoltenLight‎, 01-25-2017 11:40 AM
    • Replies: 0
    • Views: 779
    01-25-2017, 11:40 AM Go to last post

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