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Forum: Biostatistics

Epidemiology and biostatistics, public health research. GLM, logistic regression, survival analysis, clinical trials.

  1. Testing for trend

    I have following data that represent number of new patients with rare disease for subsequent 5 year time periods: 4, 3, 4, 2, 4, 2, 4, 6, 11 As I...

    Started by Markica85‎, 02-25-2017 09:25 AM
    • Replies: 5
    • Views: 188
    Yesterday, 06:06 AM Go to last post
  2. Test negative factors among correlated determinants

    Dear all, I am working on the obesity research. I found a molecule A that is negatively control the generation of adipocytes. I have a cohort of...

    Started by pinetop‎, 02-25-2017 12:05 AM
    correlation, negative, regression
    • Replies: 0
    • Views: 94
    02-25-2017, 12:05 AM Go to last post
  3. Analysis of Repeated Measures Study with Unequal Time Between Measurements

    Hello Everyone, I have inherited the analysis of a study from a previous research student. I am having trouble determining what type of analysis...

    Started by rafreakijones‎, 02-10-2017 12:42 PM
    • Replies: 1
    • Views: 161
    02-24-2017, 09:56 PM Go to last post
  4. Statistical method to compare two experiments

    I have two data from biological experiment where two types of cells were measured. For each cell the data about composition of the membrane where...

    Started by magruc‎, 02-22-2017 04:23 AM
    • Replies: 1
    • Views: 122
    02-24-2017, 04:04 PM Go to last post
  5. Moran's I Spatial Autocorrelation. Interpreting results.

    I have carried out a Moran's I test on the residuals of a GLM model in the "ape" package in R which has returned the output below: Observed:...

    Started by avocadorose‎, 02-22-2017 02:16 PM
    glm, interpretation, spatial autocorrelation
    • Replies: 1
    • Views: 129
    02-23-2017, 06:40 AM Go to last post
  6. Correct application of multiple testing methods in projects with several experiments

    Hi! I have a problem with evaluating how I should correct my alpha and conduct statistical texts when I have several different exeriments in the...

    Started by Szkeptik‎, 02-23-2017 04:32 AM
    anova, holm-bonferroni method, multiple testing
    • Replies: 0
    • Views: 83
    02-23-2017, 04:32 AM Go to last post
  7. ADjusting for variables in regression model

    Dear all, I'm comparing two populations of oncologic patients that were treated with two different regimens in two different hospitals, group A of...

    Started by Markica85‎, 02-13-2017 06:43 AM
    • Replies: 6
    • Views: 392
    02-22-2017, 01:56 PM Go to last post
  8. Can I combine univariate and multivariate HR?

    Hi guys. I'm doing a meta-analysis of survival based on a blood marker, and not all the studies have provided a multivariate hazard ratio. Some have...

    Started by ngmowbray‎, 02-21-2017 07:38 AM
    medical statistics, meta analysis
    • Replies: 6
    • Views: 167
    02-21-2017, 09:08 PM Go to last post
  9. Categorical Variable with Repeated Data Points

    Hello, I have some data (continuous DV, nominal IV), that I would like to run an ANOVA or regression on. Strictly speaking, I have 3 levels, but...

    Started by StatsN00bie‎, 02-15-2017 03:22 PM
    • Replies: 1
    • Views: 209
    02-15-2017, 05:40 PM Go to last post
  10. Clinical decision interval

    Hi all, I have a question regarding clinical decision intervals (grey zone). We have developed a new screening test and we want to provide the...

    Started by Vbogaert‎, 02-08-2017 02:41 AM
    • Replies: 1
    • Views: 199
    02-13-2017, 08:24 AM Go to last post
  11. Assessing covariates to include in model

    Hi all, I have a couple of basic questions which would be great to get some help on I have a continuous outcome (brain volume: total and divided...

    Started by Alanine‎, 02-09-2017 10:47 AM
    • Replies: 2
    • Views: 170
    02-10-2017, 06:57 AM Go to last post
  12. Question [RNA-Seq] Sparse (discrete) p values with Cuffdiff

    Hello biostatisticians, I have run a very standard RNA-Seq protocol using TopHat - Cufflinks - Cuffmerge and Cuffdiff to measure differential gene...

    Started by FR_myologist‎, 02-08-2017 02:49 PM
    • Replies: 0
    • Views: 145
    02-08-2017, 02:49 PM Go to last post
  13. propensity matching and ITT for cohort study

    I am reviewing a cohort study that used a retrospective database to determine if treatment with hypothermia post cardiac arrest improves survival to...

    Started by Roundtoit‎, 02-06-2017 04:49 PM
    itt, propensity score matching, sensitivity analysis, survival analysis
    • Replies: 0
    • Views: 173
    02-06-2017, 04:49 PM Go to last post
  14. fixed vs mixed random effects model

    greetings, I am reviewing some meta-analysis and have a question regarding fixed vs random effects models. 2 reviews have used basically the same...

    Started by Roundtoit‎, 02-05-2017 08:12 PM
    • Replies: 4
    • Views: 248
    02-06-2017, 04:45 PM Go to last post
  15. Compensate for correlated observations

    Dear users I have an issue that I am not to solve alone and I am here to ask for your help. I work in the ophthalmology field and I have a group of...

    Started by rabiolo.alessandro‎, 01-30-2017 07:09 PM
    • Replies: 4
    • Views: 422
    02-01-2017, 03:28 PM Go to last post
  16. Proper analysis method for dataset involving multiple sessions

    I have a dataset that was collected over 5 discrete sessions, with each session collected on a different date. During each session, 10 human subjects...

    Started by statsSeeker‎, 01-31-2017 03:01 PM
    multiple sessions
    • Replies: 0
    • Views: 217
    01-31-2017, 03:01 PM Go to last post
  17. Ratio between control and treatment siginificantly different than 1

    I would like to know what kind of test I can use to verify my findings. In general I have a two group of people. One is a control group the other one...

    Started by Shaxi Liver‎, 01-26-2017 10:10 AM
    • Replies: 2
    • Views: 340
    01-27-2017, 04:43 PM Go to last post
  18. Equivalence test or non inferiority test for non parametric data using stata or spss

    I am doing a retrospective study about a new medical device, comparing it with an older device. the first group has 18 cases and the other group has...

    Started by drAmrBadawy‎, 01-25-2017 09:25 PM
    • Replies: 4
    • Views: 304
    01-26-2017, 12:08 AM Go to last post
  19. McNemar or Chi sqared test for case-control study

    Dear all, I'm facing a dilemma which test would be appropriate to compare frequency of a feature in two age, sex and...

    Started by Markica85‎, 01-20-2017 06:59 AM
    • Replies: 5
    • Views: 494
    01-25-2017, 02:57 PM Go to last post
  20. Issues with ANOVA and bounded variables (percentages)

    Hey all, I’m new here. I have an issue with a percentages and the use of ANOVA. But let’s start from the beginning. I m a PhD Student and I study...

    Started by MoltenLight‎, 01-25-2017 11:40 AM
    • Replies: 0
    • Views: 175
    01-25-2017, 11:40 AM Go to last post
  21. How to combine more datasets

    Hi everyone, I’m quite sorry for this very “beginner question” , but I’m stuck on it from several days. I got three experimental groups, four...

    Started by Lodeacca‎, 01-24-2017 06:39 AM
    • Replies: 1
    • Views: 198
    01-24-2017, 08:05 AM Go to last post
  22. Exclamation Evaluation of correlation trend

    I would like to ask you for help and advice regarding one comment I received during the peer-review process for manuscript I submitted. My colleagues...

    Started by mzmph‎, 01-21-2017 07:19 PM
    correlation analysis
    • Replies: 1
    • Views: 278
    01-22-2017, 07:43 PM Go to last post
  23. Clinical Trial Simulator - Your feedback is welcomed!

    Hi all I hope it's alright if I introduce my clinical trial simulator app here. It's free and you can use it online to simulate a trial, check it...

    Started by mzhKU‎, 01-15-2017 11:33 AM
    • Replies: 4
    • Views: 495
    01-22-2017, 10:40 AM Go to last post
  24. Shiny App - Forest Plots

    Hi I've created a shiny app a while back that will create forest plots based on user supplied data through (a) uploading a data file (b)...

    Started by jamesmartinn‎, 01-16-2017 09:06 AM
    • Replies: 0
    • Views: 314
    01-16-2017, 09:06 AM Go to last post
  25. correlation study - Is my sample size too small?

    Hi there! i'm a pediatrician working in the neonatal ward, and i've recently finished aquiring data about a study that i'm doing - i'm trying to...

    Started by galkim‎, 01-15-2017 04:39 AM
    • Replies: 4
    • Views: 352
    01-16-2017, 02:17 AM Go to last post
  26. Multilinear regression?

    Hi, all: I need help for my research. I would like to develop an analytical method to detect the toxin A metabolites in exposed human urine; I...

    Started by ybz12003‎, 01-14-2017 06:34 PM
    • Replies: 1
    • Views: 286
    01-15-2017, 07:05 AM Go to last post
  27. Power analysis with one and two variables?

    Hi gang, I am severely illiterate in stats and so am struggling with what would seem to be a very straightforward problem. My problem: We...

    Started by ablum‎, 01-04-2017 04:18 PM
    • Replies: 1
    • Views: 519
    01-11-2017, 04:50 PM Go to last post
  28. Question on Odds ratio

    Hi, I have a basic understanding of odds ratio. I can't figure out how to integrate the space S into my odds ratio equation. For the following...

    Started by MinieMe‎, 01-10-2017 01:13 PM
    biostatistics, odds ratio
    • Replies: 2
    • Views: 310
    01-10-2017, 02:38 PM Go to last post
  29. Post What statistical test to use for species abundance between wet and dry season?

    Sorry if this question is trivial, I have a collection of camera trap data of recorded species during the rainy season and the dry season. I am...

    Started by BondHR‎, 01-07-2017 10:24 PM
    abundance, camera trap data, rstats, species data, statistics
    • Replies: 5
    • Views: 473
    01-08-2017, 02:38 PM Go to last post
  30. Temporal Distribution of Death

    Dear all, I plan to conduct a study. The preliminary aim is to examine the temporal distribution of death of terminal cancer patients in hospice...

    Started by bestmic‎, 12-20-2016 06:40 AM
    • Replies: 10
    • Views: 853
    01-03-2017, 04:40 AM Go to last post
  31. Add AUCs

    I want to add Area Under the Curve (AUC) from multiple meta analyses. AUC for each Meta analysis is given. How can I add them together?

    Started by Michael_svm‎, 12-20-2016 05:24 AM
    area under the curve, auc, diagnostic, roc
    • Replies: 6
    • Views: 688
    12-23-2016, 08:08 AM Go to last post
  32. Patterns in DNA, seperating signal from noise -- outliers?

    Hello all, I'm looking at patterns in fragments of RNA. What I need to do is separate the signals from noise in Exons (small regions of DNA/RNA)....

    Started by James1984‎, 10-10-2015 06:30 PM
    • Replies: 2
    • Views: 839
    12-22-2016, 05:05 AM Go to last post
  33. t-test or z-test for two proportions?

    We did an intervention to reduce the frequency of use of a certain type of treatment and now I want to compare the data pre vs post intervention. ...

    Started by hurricanemb‎, 12-18-2016 03:28 PM
    proportions, t-test, z-test
    • Replies: 3
    • Views: 460
    12-19-2016, 11:01 AM Go to last post
  34. Red face Interpreting Odds Ratios... weird question

    Hi, I sort of have a weird question. I have a basic understanding of ORs, and can interpret them, but it's never been clear to me why we...

    Started by Ceci18‎, 12-14-2016 10:34 AM
    • Replies: 6
    • Views: 598
    12-16-2016, 11:37 AM Go to last post
  35. Area under Kaplan Meier curve

    There is one thing bothering me for some time: What does area under Kaplan-Meier survival curve actally represent? Is there a plausible way to...

    Started by Markica85‎, 12-10-2016 05:55 AM
    kaplan meier, survival analysis
    • Replies: 0
    • Views: 634
    12-10-2016, 05:55 AM Go to last post
  36. Pooling time points to perform a Fisher test?

    Hello, I am currently trying to analyse an experiment to assess if rats with cerebral malformations have a sensitivity deficit on one of their...

    Started by Fanny-‎, 12-07-2016 12:10 PM
    anova, chi-square, fisher test
    • Replies: 4
    • Views: 600
    12-09-2016, 03:58 AM Go to last post
  37. What kind of statistical test can be used for my data?

    It is my first post on this forum so please be gentle. If it is not a proper section I would appreciate if moderator moves the thread to the correct...

    Started by Shaxi Liver‎, 12-07-2016 11:56 AM
    • Replies: 1
    • Views: 428
    12-07-2016, 01:27 PM Go to last post
  38. How to obtain an unbiased post-stratified estimator for survival probabilities?

    Suppose I have estimated the survival probabilities $\hat{S(t)}_1, \hat{S(t)}_2, \ldots, \hat{S(t)}_H$ from $H$ strata. Now I want to get an unbiased...

    Started by Blain Waan‎, 08-12-2016 09:14 PM
    estimator, stratification, survival
    • Replies: 3
    • Views: 826
    12-06-2016, 11:07 AM Go to last post
  39. Why not use Kaplan Meier?

    In the method described here http://dmkd.cs.vt.edu/papers/TKDE17.pdf R code implementation is provided ...

    Started by pablrodr‎, 12-02-2016 04:07 PM
    exponential distribution, kaplan meier, weibull distribution
    • Replies: 5
    • Views: 536
    12-03-2016, 09:56 AM Go to last post
  40. Bird Community Ecology - BACI experiment

    Greetings! I'm currently trying to investigate the impact of an event on the bird community of a National Park on my country. For that I have...

    Started by Fsmelo‎, 12-02-2016 10:36 AM
    baci, community ecology, ecology
    • Replies: 2
    • Views: 458
    12-02-2016, 03:19 PM Go to last post
  41. How to use chi-square test correspondence between features and response in R?

    There is a set of tumors,each one includes five features, which relate to one gene type result. Tumor Feature 1 ... Feature 5 Gene type 1 ...

    Started by l35633‎, 11-27-2016 12:56 PM
    chi-square, features, response
    • Replies: 0
    • Views: 528
    11-27-2016, 12:56 PM Go to last post
  42. MDS vs ANOVA / GLM methods - how and why?

    Hello to all :wave: I am a new member of this forum and the reason why I ended up here is the following: like many others, I am in desperate need of...

    Started by caralynne‎, 11-26-2016 06:17 AM
    • Replies: 0
    • Views: 504
    11-26-2016, 06:17 AM Go to last post
  43. How the estimate a smple size ?

    Hi everybody; I am a PhD student, my thesis focuses on the study of reproductive health among teenagers girls . For that, I'am going to work in...

    Started by siham‎, 11-24-2016 05:41 PM
    • Replies: 2
    • Views: 542
    11-25-2016, 12:15 PM Go to last post
  44. Help with linear model

    Hi guys, I'm really struggling with the relevant coding for this, I'm using Rstudio. I need a Linear model with Gaussian error structure to find...

    Started by imbricata‎, 11-07-2016 05:07 AM
    • Replies: 1
    • Views: 574
    11-23-2016, 10:51 AM Go to last post
  45. Model Selection in Survival Analysis

    I'm having trouble with parametric model selection in survival analysis. I founded this sequence of steps in some presentation. This is an...

    Started by askazy‎, 11-20-2016 02:53 PM
    • Replies: 1
    • Views: 502
    11-23-2016, 10:44 AM Go to last post
  46. estimating start point of a production of y" -ie findx for y=0 given y values for x>0

    I hope I can explain the problem clearly and its not an obvious solution. the application area is say an event (in the body) at say day=0 starts the...

    Started by azStats‎, 11-07-2016 09:47 AM
    regression
    • Replies: 3
    • Views: 555
    11-23-2016, 04:29 AM Go to last post
  47. Help with calculating probability?

    I have a strange set of data, it was counting the number of animals entering and leaving a shelter as a 'count' of how many were in the shelter. We...

    Started by zoologist‎, 11-22-2016 07:55 PM
    • Replies: 0
    • Views: 443
    11-22-2016, 07:55 PM Go to last post
  48. Exclamation Experimental design: Gender comparison in a novel memory matrix.

    Hello, I am a medical student who knows very little about biostats and would like some one to tell me whether my analysis for my research makes...

    Started by Syeda‎, 11-20-2016 06:13 AM
    • Replies: 4
    • Views: 553
    11-22-2016, 07:55 AM Go to last post
  49. Proportional hazards and Cox Model

    I'm trying to fit a Cox model, but there is some problems. I have the following variables in the model. - Group: 1, 2, ..., 9 - Sex: 1 female...

    Started by askazy‎, 11-09-2016 04:29 PM
    • Replies: 5
    • Views: 906
    11-10-2016, 12:42 PM Go to last post
  50. Cumulative Incidence with Confidence Intervals when using IPTW

    Dear Stata users, I'm doing a time to event analysis with inverse probability of treatment weights(IPTW) estimated with propensity scores from a...

    Started by Soren‎, 11-10-2016 10:41 AM
    cumulative incidence, iptw, propensity scores
    • Replies: 2
    • Views: 513
    11-10-2016, 12:01 PM Go to last post
  51. Help with setting my study!

    Hi all, I'm a newbie to biostatistics and I'm trying to figure out how to set the statistical part of my final project. I'm a dentistry student and...

    Started by Deepchamfer‎, 11-08-2016 09:14 AM
    • Replies: 1
    • Views: 526
    11-08-2016, 09:16 AM Go to last post
  52. Parallel and subsequential diagnostic tests

    Hey guys, i just ran into a problem: I am having two predictive models: Model 1: Sensitivity: 0.8 Specificity: 0.4

    Started by lilchaos‎, 11-02-2016 10:25 AM
    • Replies: 12
    • Views: 844
    11-08-2016, 02:59 AM Go to last post
  53. Dataset for statistical analysis

    Dear all, I work in Rome for the Italian National Health Service (www.iss.it); I am currently working on a European clinic project called EMTICS...

    Started by mtallon‎, 10-17-2016 03:09 PM
    • Replies: 4
    • Views: 781
    11-07-2016, 04:55 AM Go to last post
  54. Please help me select the correct statistical test

    I'm a general surgery resident and am conducting a quality improvement study about waste in the OR. My statistics background is limited to what I was...

    Started by billingsmd‎, 11-06-2016 05:59 PM
    • Replies: 5
    • Views: 601
    11-07-2016, 02:08 AM Go to last post
  55. Medical news story - Is this an OK way to report the stats?

    I'm a medical writer covering an upcoming research paper. I'm new to the forum, so please LMK if this is not an appropriate place for my question. ...

    Started by tobmed‎, 11-04-2016 09:49 AM
    • Replies: 2
    • Views: 611
    11-04-2016, 01:40 PM Go to last post
  56. Observed difference between two test for same patient is due to chance?

    Hi, I have results from two very sensitive but different lab test trying to find pathogen in a patient sample. For some patients results from two...

    Started by deepbiomed‎, 11-02-2016 02:02 PM
    • Replies: 0
    • Views: 490
    11-02-2016, 02:02 PM Go to last post
  57. likelihood ratio test and AIC

    Can somebody please help me answer the question in the attachment. I have a test next week. please help

    Started by Jeff Hardy‎, 10-31-2016 12:47 PM
    • Replies: 5
    • Views: 643
    11-02-2016, 12:40 PM Go to last post
  58. Help with correct model formula for a repeated measures design

    Hi there, I will really appreciate some help denoting the proper formula to fit a GLM for the following repeated measures data: I investigated...

    Started by phmontoya‎, 11-01-2016 11:45 AM
    • Replies: 0
    • Views: 497
    11-01-2016, 11:45 AM Go to last post
  59. Question about sample size penalty for looking at data mid-trial

    Hi, we're running a clinical trial for a skin treatment with a medical device that has a strong effect. We are using an inter-patient control (no...

    Started by bma449‎, 10-24-2016 05:58 PM
    interim analysis
    • Replies: 3
    • Views: 690
    10-29-2016, 02:08 PM Go to last post
  60. Help with regards to deciding appropriate statistical test for success criteria

    Hello, I have the collective data of 35 eyes that underwent trabeculectomy surgery for glaucoma control. There is no control group, and...

    Started by neosage‎, 10-27-2016 02:27 PM
    • Replies: 1
    • Views: 517
    10-27-2016, 06:00 PM Go to last post

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