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Forum: Biostatistics

Epidemiology and biostatistics, public health research. GLM, logistic regression, survival analysis, clinical trials.

  1. what statistical test to choose

    Hi all, I am working on a similar kind of project as this https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313376/ For table 2, what are the...

    Started by bburugap‎, Today 02:15 PM
    • Replies: 0
    • Views: 19
    Today, 02:15 PM Go to last post
  2. Can i use one sample t-test?

    Hi all Currently im doing a research to see how effective my results as compared to the mean value and standard deviation of previous study. ...

    Started by hnw‎, 04-20-2017 04:41 AM
    one sample t test
    • Replies: 2
    • Views: 191
    04-20-2017, 08:16 AM Go to last post
  3. Different proportions in different conditions?

    Hi, I am struggling with the proper way to analyze my data. I did some research in and out of this forum but could not find the answer to my...

    Started by Fanny-‎, 04-11-2017 08:06 AM
    • Replies: 1
    • Views: 247
    04-18-2017, 11:13 AM Go to last post
  4. Question reference interval determination

    Hi all, I was wondering if I could ask for some help from some more statistically inclined persons than myself. We are trying to determine a...

    Started by romes‎, 03-25-2017 10:23 AM
    biostatistics, reference interval
    • Replies: 1
    • Views: 313
    04-16-2017, 08:32 AM Go to last post
  5. Problem with normalization and - proteomics analysis (LC-MS)

    Hi folks, I am working with proteomics data, containing mainly LC-MS and NMRI analysis. Firstly, I must normalise data to give valuable compound...

    Started by robertp‎, 04-15-2017 11:04 AM
    biostatistics, data analysis, nmri, normalization, proteomics
    • Replies: 0
    • Views: 100
    04-15-2017, 11:04 AM Go to last post
  6. Bias Question

    My statistics teacher and I are at a disagreement with an answer to one of his questions and I was wondering if you all could help me out. The...

    Started by jimsam321‎, 04-12-2017 04:55 PM
    • Replies: 14
    • Views: 322
    04-13-2017, 09:29 AM Go to last post
  7. Question Comparing groups - Should I do hypotesis testing on raw counts or percentage values?

    Hi, first post here, and I really hope you can help me with this. I'm measuring the number of cells labelled with two markers (let's call them A...

    Started by sgomes‎, 04-10-2017 10:37 AM
    • Replies: 3
    • Views: 241
    04-10-2017, 04:57 PM Go to last post
  8. Chi Square test (not significant when comparing across 4 groups but changes with 2)

    Hi all, I was conducting a chi-square + fisher test and ran across a problem: I am using a chi square to test whether or not there is an...

    Started by Nives_ES‎, 04-07-2017 11:45 AM
    • Replies: 2
    • Views: 281
    04-07-2017, 02:08 PM Go to last post
  9. Statistical help (not independent samples)

    Hello all, I need some help in understanding what statistical test to use when I have 3 groups and the groups are not independent of each other...

    Started by bburugap‎, 04-01-2017 02:40 PM
    • Replies: 2
    • Views: 303
    04-05-2017, 04:04 PM Go to last post
  10. How to do age standardization for morbidity study (2 populations)

    Good day all, I have a question in regards to age standardization. My study is on morbidity(disease) and I have 2 populations. The populations are...

    Started by happiness17‎, 04-04-2017 04:47 AM
    • Replies: 0
    • Views: 148
    04-04-2017, 04:47 AM Go to last post
  11. Unhappy Which test for equivalency?

    I have two machines A & B. 5 patients. I calculate the elasticity of their skin with the two different machines. This gives me two numbers per...

    Started by yolo123‎, 04-01-2017 07:00 PM
    • Replies: 6
    • Views: 340
    04-02-2017, 04:15 PM Go to last post
  12. PCA questions?

    Hi there, I am a bit new to statistics and have a few questions. I am currently doing my dissertation on the consistent and variable...

    Started by Callum94‎, 03-29-2017 12:59 PM
    • Replies: 3
    • Views: 358
    03-29-2017, 06:36 PM Go to last post
  13. Predicting outcome with multiple groups

    Hi everyone, I'm currently working with 3 different groups (3 disease populations) and I would like to predict which of the three groups they fall...

    Started by Eric2014‎, 03-28-2017 12:14 PM
    groups, logistic, prediction, regression
    • Replies: 4
    • Views: 262
    03-28-2017, 03:45 PM Go to last post
  14. Finding data given sample mean and variance

    Hello, I have a problem, I am given the sample size, mean, variance, and I know it is normally distributed. The question states that 160...

    Started by dorothy8‎, 03-26-2017 06:56 PM
    • Replies: 2
    • Views: 237
    03-27-2017, 09:56 PM Go to last post
  15. am i overadjusting?

    might sound silly but for my research topic I am looking into insulin resistance (IR) and dietary factors. We are measuring IR by the use of...

    Started by jkerr1‎, 03-27-2017 04:56 AM
    • Replies: 1
    • Views: 206
    03-27-2017, 10:23 AM Go to last post
  16. Confidence interval question

    Fr a sample of 100 hypertensive patients, we find that a 95% confidence interval of systolic BP to be . What statement is FALSE? A- if a drug is...

    Started by dorothy8‎, 03-26-2017 05:53 PM
    • Replies: 1
    • Views: 193
    03-27-2017, 02:20 AM Go to last post
  17. Pre and post comparison for nonparametric unpaired sample

    Hi. I am not sure how to compare the results from the following study. Number of wrong orders out of total orders placed every day for 60 days as...

    Started by anupamsule‎, 03-22-2017 09:01 PM
    • Replies: 2
    • Views: 377
    03-24-2017, 07:04 AM Go to last post
  18. Dealing with Log(0)

    Dear all, Iíve been stuck for quite some time with a problem that relates to use of log-scale with values that equal zero. My data comes from an...

    Started by ritmaniac‎, 03-21-2017 07:21 AM
    anova, linear regression, logarithmic
    • Replies: 2
    • Views: 354
    03-21-2017, 04:22 PM Go to last post
  19. Sample size calculation for 1:2 matched case-control study

    Hi, I have a matched case-control study with 12 cases and two controls for each case. Evaluating our findings, I want to calculate what our sample...

    Started by teapot‎, 03-08-2017 02:22 PM
    • Replies: 7
    • Views: 733
    03-17-2017, 08:59 AM Go to last post
  20. stratified log-rank test and proportional hazards

    Does stratified log-rank test overcome problem of violation of proportional hazards? I encountered a randomized controlled study of a new drug...

    Started by Markica85‎, 03-16-2017 04:53 AM
    • Replies: 0
    • Views: 297
    03-16-2017, 04:53 AM Go to last post
  21. Regarding Maximum Percent different

    Dear all, Could you please explain what maximum percent different for continues vital DiaBP data. How to calculate this? Could you any one...

    Started by Statvijay‎, 03-14-2017 07:08 AM
    • Replies: 0
    • Views: 218
    03-14-2017, 07:08 AM Go to last post
  22. Survival Analysis - Time to utilization of medical services

    Hi all, I work in the medical field and Iím looking into using survival analysis calculate time to utilization of medical services, that is, once...

    Started by avbraga‎, 03-10-2017 04:35 PM
    • Replies: 6
    • Views: 353
    03-13-2017, 06:07 PM Go to last post
  23. vision in eyes at different times

    Hi everyone, New to the forum and am seeking a bit of guidance as to how to compare vision (visual acuity) between eyes. So I am trying to...

    Started by jksgoh‎, 03-11-2017 02:44 AM
    • Replies: 1
    • Views: 297
    03-13-2017, 02:42 PM Go to last post
  24. Which statistical tests are appropriate: Group means before and after treatment

    I am trying to find out what statistical tests to run on a set of aggregate data (no individual data) on 3 different groups, variables are summarized...

    Started by PamelaF‎, 03-07-2017 04:17 AM
    • Replies: 1
    • Views: 432
    03-09-2017, 04:31 PM Go to last post
  25. Adjustment for correlated data in meta-anlaysis

    Hi, I'm completing a systematic review and performing meta-anlaysis forest plots. The research question related to the finding of risk factors for...

    Started by Ainslie‎, 03-08-2017 12:47 AM
    adjustment, correlated data, meta-analysis
    • Replies: 2
    • Views: 383
    03-08-2017, 11:07 AM Go to last post
  26. standard deviation greater than variance, is this ok?

    I am putting together some audit results and it was suggested I present them as mean +/- SD. However there is a significant variance in the results....

    Started by Roundtoit‎, 03-07-2017 05:44 PM
    • Replies: 7
    • Views: 529
    03-08-2017, 04:23 AM Go to last post
  27. Comparing diagnostic tests - graphically demonstration

    Hi, This is very basic but really struggling to find the correct terminology to find out what I want to do. I have collected data on two methods...

    Started by k093‎, 03-07-2017 07:17 PM
    • Replies: 0
    • Views: 274
    03-07-2017, 07:17 PM Go to last post
  28. interpretation of a negative risk difference

    Hi, I am reviewing a cohort study and trying to make sense of the results. When considering mortality they presented their results as a risk...

    Started by Roundtoit‎, 03-05-2017 03:10 PM
    biostatistics, cohort study, risk difference
    • Replies: 1
    • Views: 382
    03-05-2017, 04:02 PM Go to last post
  29. Correct application of multiple testing methods in projects with several experiments

    Hi! I have a problem with evaluating how I should correct my alpha and conduct statistical texts when I have several different exeriments in the...

    Started by Szkeptik‎, 02-23-2017 04:32 AM
    anova, holm-bonferroni method, multiple testing
    • Replies: 1
    • Views: 438
    03-04-2017, 10:36 PM Go to last post
  30. Smile Comparative study

    Im doing comparative study of Kidney disease and Dermatoglyphics. There is a Continuous variable (ridge count) i am assessing Confounding factors is...

    Started by buddhikatbw‎, 03-03-2017 09:24 AM
    case control study
    • Replies: 2
    • Views: 334
    03-03-2017, 09:36 PM Go to last post
  31. matched pre-post survey analysis help

    I have matched pre-and post test data that evaluated our workshop participants using Likert-type items. Meaning, the same people were given the same...

    Started by hipstats‎, 02-28-2017 05:10 PM
    • Replies: 3
    • Views: 396
    03-03-2017, 08:52 AM Go to last post
  32. Test negative factors among correlated determinants

    Dear all, I am working on the obesity research. I found a molecule A that is negatively control the generation of adipocytes. I have a cohort of...

    Started by pinetop‎, 02-25-2017 12:05 AM
    correlation, negative, regression
    • Replies: 1
    • Views: 405
    03-02-2017, 01:41 PM Go to last post
  33. Cox regression to adjust for site effect in multicenter trial

    Hello All, Can stratified Cox regression be used to adjust for site effect in multicenter trials? Thank you in advance to all those who reply.

    Started by ineedhelpplease‎, 02-27-2017 10:44 PM
    • Replies: 3
    • Views: 635
    02-28-2017, 05:34 PM Go to last post
  34. Testing for trend

    I have following data that represent number of new patients with rare disease for subsequent 5 year time periods: 4, 3, 4, 2, 4, 2, 4, 6, 11 As I...

    Started by Markica85‎, 02-25-2017 09:25 AM
    • Replies: 12
    • Views: 910
    02-28-2017, 01:30 PM Go to last post
  35. Analysis of Repeated Measures Study with Unequal Time Between Measurements

    Hello Everyone, I have inherited the analysis of a study from a previous research student. I am having trouble determining what type of analysis...

    Started by rafreakijones‎, 02-10-2017 12:42 PM
    • Replies: 1
    • Views: 397
    02-24-2017, 09:56 PM Go to last post
  36. Statistical method to compare two experiments

    I have two data from biological experiment where two types of cells were measured. For each cell the data about composition of the membrane where...

    Started by magruc‎, 02-22-2017 04:23 AM
    • Replies: 1
    • Views: 386
    02-24-2017, 04:04 PM Go to last post
  37. Moran's I Spatial Autocorrelation. Interpreting results.

    I have carried out a Moran's I test on the residuals of a GLM model in the "ape" package in R which has returned the output below: Observed:...

    Started by avocadorose‎, 02-22-2017 02:16 PM
    glm, interpretation, spatial autocorrelation
    • Replies: 1
    • Views: 454
    02-23-2017, 06:40 AM Go to last post
  38. ADjusting for variables in regression model

    Dear all, I'm comparing two populations of oncologic patients that were treated with two different regimens in two different hospitals, group A of...

    Started by Markica85‎, 02-13-2017 06:43 AM
    • Replies: 6
    • Views: 790
    02-22-2017, 01:56 PM Go to last post
  39. Can I combine univariate and multivariate HR?

    Hi guys. I'm doing a meta-analysis of survival based on a blood marker, and not all the studies have provided a multivariate hazard ratio. Some have...

    Started by ngmowbray‎, 02-21-2017 07:38 AM
    medical statistics, meta analysis
    • Replies: 6
    • Views: 426
    02-21-2017, 09:08 PM Go to last post
  40. Categorical Variable with Repeated Data Points

    Hello, I have some data (continuous DV, nominal IV), that I would like to run an ANOVA or regression on. Strictly speaking, I have 3 levels, but...

    Started by StatsN00bie‎, 02-15-2017 03:22 PM
    • Replies: 1
    • Views: 516
    02-15-2017, 05:40 PM Go to last post
  41. Clinical decision interval

    Hi all, I have a question regarding clinical decision intervals (grey zone). We have developed a new screening test and we want to provide the...

    Started by Vbogaert‎, 02-08-2017 02:41 AM
    • Replies: 1
    • Views: 410
    02-13-2017, 08:24 AM Go to last post
  42. Assessing covariates to include in model

    Hi all, I have a couple of basic questions which would be great to get some help on I have a continuous outcome (brain volume: total and divided...

    Started by Alanine‎, 02-09-2017 10:47 AM
    • Replies: 2
    • Views: 427
    02-10-2017, 06:57 AM Go to last post
  43. Question [RNA-Seq] Sparse (discrete) p values with Cuffdiff

    Hello biostatisticians, I have run a very standard RNA-Seq protocol using TopHat - Cufflinks - Cuffmerge and Cuffdiff to measure differential gene...

    Started by FR_myologist‎, 02-08-2017 02:49 PM
    • Replies: 0
    • Views: 470
    02-08-2017, 02:49 PM Go to last post
  44. propensity matching and ITT for cohort study

    I am reviewing a cohort study that used a retrospective database to determine if treatment with hypothermia post cardiac arrest improves survival to...

    Started by Roundtoit‎, 02-06-2017 04:49 PM
    itt, propensity score matching, sensitivity analysis, survival analysis
    • Replies: 0
    • Views: 473
    02-06-2017, 04:49 PM Go to last post
  45. fixed vs mixed random effects model

    greetings, I am reviewing some meta-analysis and have a question regarding fixed vs random effects models. 2 reviews have used basically the same...

    Started by Roundtoit‎, 02-05-2017 08:12 PM
    • Replies: 4
    • Views: 660
    02-06-2017, 04:45 PM Go to last post
  46. Compensate for correlated observations

    Dear users I have an issue that I am not to solve alone and I am here to ask for your help. I work in the ophthalmology field and I have a group of...

    Started by rabiolo.alessandro‎, 01-30-2017 07:09 PM
    • Replies: 4
    • Views: 947
    02-01-2017, 03:28 PM Go to last post
  47. Proper analysis method for dataset involving multiple sessions

    I have a dataset that was collected over 5 discrete sessions, with each session collected on a different date. During each session, 10 human subjects...

    Started by statsSeeker‎, 01-31-2017 03:01 PM
    multiple sessions
    • Replies: 0
    • Views: 465
    01-31-2017, 03:01 PM Go to last post
  48. Ratio between control and treatment siginificantly different than 1

    I would like to know what kind of test I can use to verify my findings. In general I have a two group of people. One is a control group the other one...

    Started by Shaxi Liver‎, 01-26-2017 10:10 AM
    • Replies: 2
    • Views: 846
    01-27-2017, 04:43 PM Go to last post
  49. Equivalence test or non inferiority test for non parametric data using stata or spss

    I am doing a retrospective study about a new medical device, comparing it with an older device. the first group has 18 cases and the other group has...

    Started by drAmrBadawy‎, 01-25-2017 09:25 PM
    • Replies: 4
    • Views: 883
    01-26-2017, 12:08 AM Go to last post
  50. McNemar or Chi sqared test for case-control study

    Dear all, I'm facing a dilemma which test would be appropriate to compare frequency of a feature in two age, sex and...

    Started by Markica85‎, 01-20-2017 06:59 AM
    • Replies: 5
    • Views: 1,128
    01-25-2017, 02:57 PM Go to last post
  51. Issues with ANOVA and bounded variables (percentages)

    Hey all, Iím new here. I have an issue with a percentages and the use of ANOVA. But letís start from the beginning. I m a PhD Student and I study...

    Started by MoltenLight‎, 01-25-2017 11:40 AM
    • Replies: 0
    • Views: 502
    01-25-2017, 11:40 AM Go to last post
  52. How to combine more datasets

    Hi everyone, Iím quite sorry for this very ďbeginner questionĒ , but Iím stuck on it from several days. I got three experimental groups, four...

    Started by Lodeacca‎, 01-24-2017 06:39 AM
    • Replies: 1
    • Views: 497
    01-24-2017, 08:05 AM Go to last post
  53. Exclamation Evaluation of correlation trend

    I would like to ask you for help and advice regarding one comment I received during the peer-review process for manuscript I submitted. My colleagues...

    Started by mzmph‎, 01-21-2017 07:19 PM
    correlation analysis
    • Replies: 1
    • Views: 742
    01-22-2017, 07:43 PM Go to last post
  54. Clinical Trial Simulator - Your feedback is welcomed!

    Hi all I hope it's alright if I introduce my clinical trial simulator app here. It's free and you can use it online to simulate a trial, check it...

    Started by mzhKU‎, 01-15-2017 11:33 AM
    • Replies: 4
    • Views: 1,139
    01-22-2017, 10:40 AM Go to last post
  55. Shiny App - Forest Plots

    Hi I've created a shiny app a while back that will create forest plots based on user supplied data through (a) uploading a data file (b)...

    Started by jamesmartinn‎, 01-16-2017 09:06 AM
    • Replies: 0
    • Views: 777
    01-16-2017, 09:06 AM Go to last post
  56. correlation study - Is my sample size too small?

    Hi there! i'm a pediatrician working in the neonatal ward, and i've recently finished aquiring data about a study that i'm doing - i'm trying to...

    Started by galkim‎, 01-15-2017 04:39 AM
    • Replies: 4
    • Views: 974
    01-16-2017, 02:17 AM Go to last post
  57. Multilinear regression?

    Hi, all: I need help for my research. I would like to develop an analytical method to detect the toxin A metabolites in exposed human urine; I...

    Started by ybz12003‎, 01-14-2017 06:34 PM
    • Replies: 1
    • Views: 675
    01-15-2017, 07:05 AM Go to last post
  58. Power analysis with one and two variables?

    Hi gang, I am severely illiterate in stats and so am struggling with what would seem to be a very straightforward problem. My problem: We...

    Started by ablum‎, 01-04-2017 04:18 PM
    • Replies: 1
    • Views: 1,092
    01-11-2017, 04:50 PM Go to last post
  59. Question on Odds ratio

    Hi, I have a basic understanding of odds ratio. I can't figure out how to integrate the space S into my odds ratio equation. For the following...

    Started by MinieMe‎, 01-10-2017 01:13 PM
    biostatistics, odds ratio
    • Replies: 2
    • Views: 893
    01-10-2017, 02:38 PM Go to last post
  60. Post What statistical test to use for species abundance between wet and dry season?

    Sorry if this question is trivial, I have a collection of camera trap data of recorded species during the rainy season and the dry season. I am...

    Started by BondHR‎, 01-07-2017 10:24 PM
    abundance, camera trap data, rstats, species data, statistics
    • Replies: 5
    • Views: 1,300
    01-08-2017, 02:38 PM Go to last post

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