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    Unusual power analysis

    Thank you both for your thoughts. @hlsmith I made progress by thinking about your approach, but I am intrigued by the simplicity of @katxt approach. I think that is what I am looking for, and it seems there is some statistical work to back this up. That's a great example for Occam's razor - I...
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    Unusual power analysis

    Thanks a lot for your input. This disease (paroxysmal nocturnal hemoglobinuria) is very rare (prevalence of 1:100.00), but has a phenomenal treatment, so we want to detect it as early as possible to improve prognosis. But it does not make sense to screen for a disease with a prevalence of...
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    Unusual power analysis

    Hello, does somebody have an idea how to perform the following sample size calculations? I want to conduct a cross-sectional study in a special patient population to proof that screening for a disease does NOT make sense. So basically to exclude this disease in this special patient population...
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    Which statistical test should I use?

    I thought about the paired t-test. The problem is I would have unequal sample sizes - namely the data of the 12 months and the data of the 1 month. Wouldn't that be rather independent?
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    Which statistical test should I use?

    Thank you very much. So it is that easy ok. You are absolutely right, but it should be more of an hypothesis-generating work than actual statistical proof.
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    Which statistical test should I use?

    Hi everyone, maybe a statistical expert could help me out. I am interested in an event, that occurs in mean 30 times per month with an SD of 10. This relies on a data collected over a period of 1 year. Now I want to compare if this event happens as often after the coronavirus pandemic. So i...