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    Help in statistical design of cardiovascular research protocol please - thoughts and suggestions appreciated, as I am out of depth

    Here is the big picture - read on its interesting. People take anticoagulant drugs (ie blood thinners such as warfarin, NOACs) to reduce their chance of blood clot formation (that causes strokes) when they are diagnosed with a common heart arrhythmia called atrial fibrillation (AF). This is a...