Combine your two datasets into a single dataset, with a factor (perhaps named "set") indicating which set each observation came from. Then you want to run a model like DV ~ IV + set + IV:set, and you want to test the IV:set interaction term. This will tell you if the slope for IV differs between sets.





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. "DV ~ IV + set + IV:set" is a piece of the syntax that you would use for running this model in R, but basically it reads as a regression equation, except with ~ in place of the equal sign. So in this model we are regressing the dependent variable (DV) on the independent variable (IV), the set indicator, and the interaction between IV and set, which is what "IV:set" is supposed to represent. Is this more clear?
