If Y given x, or the residuals, are not normally distributed you can try transformations. If that does not work you can try for example a generalized linear model with gamma distribution (of Y| x).
But before you do that I suggest Flowerpower (interesting name!) tell us something about the study.
What is “HRV”? (Abbreviations!#3@*#)
Reaction time of what?
How many observations do you have in each cell (i.e. combination)? Is it the same so that the design is balanced?
Is the interaction significant or not?
Are the main effects significant?
I suggest Flowerpower pick out the females and show us box plots for each level of “HRV”.







I think (if I understood Dason correctly) in that case, despite the non-normal distribution of dependent variable, we have normal distribution of residual?
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