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Thread: Stratified log rank vs cox regression

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    Stratified log rank vs cox regression




    Hello everyone,

    I am performing a survival analysis to compare survival with two treatment regimen (with SPSS).

    With Log-rank p value is significant (p: 0,033)

    When stratified with a binary variable significance is lost (p:0,062)

    With Cox regression (backward LR method) only variable left in the model is treatment (HR: 2.4). The binary variable that is shown to effect survival outcome with stratified log rank, is not significant in cox model.

    How should I interpret that? Is the treatment significantly improve survival? Anything else to do?
    Last edited by gokhan; 10-26-2013 at 09:28 AM.

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    Re: Stratified log rank vs cox regression

    I would think seriously about whether your data meets the 'proportional hazards' assumption of cox ph model.

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    Re: Stratified log rank vs cox regression


    Variables that I have added to the model are known prognostic factors of the disease, and used in many previous studies. So I think data meets the proportional hazards assumption.
    I found this paper helpful; a quote "This method (stratified log rank) not generally regarded as a formal statistical model, but is of use where a very small number of covariates are to be considered, if only as an exploratory method of analysis."
    http://www.ncbi.nlm.nih.gov/pubmed/12888808

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