+ Reply to Thread
Results 1 to 3 of 3

Thread: Futility analysis sample size

  1. #1
    Points: 518, Level: 10
    Level completed: 36%, Points required for next Level: 32

    Posts
    5
    Thanks
    1
    Thanked 0 Times in 0 Posts

    Futility analysis sample size




    Hello,
    I have been asked to determine the sample size needed to demonstrate futility in a small study. I suggested going the "traditional route" and conducting an interim analysis at a pre-specified timepoint or sample size to determine whether or not to continue (likely via conditional power), but I'm wondering if there is a reasonable method for just providing the sample size a priori. The only thing I can think of is to determine sample size based on beta (Type II error), but I don't see how that would be different from determining sample size based on power.

    Any suggestions welcome! Thank you in advance!

  2. #2
    TS Contributor
    Points: 14,811, Level: 78
    Level completed: 91%, Points required for next Level: 39
    Miner's Avatar
    Location
    Greater Milwaukee area
    Posts
    1,171
    Thanks
    34
    Thanked 405 Times in 363 Posts

    Re: Futility analysis sample size

    Power = 1 - Beta so you will get the same answer.

  3. The Following User Says Thank You to Miner For This Useful Post:

    jcr (03-24-2015)

  4. #3
    Points: 518, Level: 10
    Level completed: 36%, Points required for next Level: 32

    Posts
    5
    Thanks
    1
    Thanked 0 Times in 0 Posts

    Re: Futility analysis sample size


    Thank you, yes, that was my concern. Do you have any other suggestions?

+ Reply to Thread

           




Tags for this Thread

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts






Advertise on Talk Stats