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Thread: Power analysis and Kaplan meier

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    Power analysis and Kaplan meier


    I need your help to compute a power analysis for survival analysis (Kaplan meier) without historical data.
    In my lab we are preparing a project in which we want to evaluate tumor free survival of two cohorts of mouse (one treated with A and one treated with B); because the experiment is new, we don't know the median tumor incidence time of the two groups.

    We want to make sure to detect at least a difference in tumor incidence of 20% between the two groups (using less mouse as possible).
    I fixed alpha=0.05 and power=0.8. How can I calculate the required sample size (using R or STATA)??
    How can I calculate the hazard ratio??

    Thank you in advance for your help!
    .. and sorry for my english errors
    Last edited by Fischer; 03-21-2016 at 05:57 AM.

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