+ Reply to Thread
Results 1 to 2 of 2

Thread: 1-sample binomial for my research data?

  1. #1
    Points: 5, Level: 1
    Level completed: 9%, Points required for next Level: 45

    Thanked 0 Times in 0 Posts

    1-sample binomial for my research data?


    Newbie here so I will try to explain as clearly as I can. I do research in the neuro field. I have a control group of neurons that I am analyzing for the presence or absence (binary) of a specific trait (let's call it trait A). I found that the control group have A 60% of the time. Now I want to look at a mutant to determine if its neurons have/don't have trait A. So I guess there are two questions here:

    1) How do I determine the sample size required for the mutant in order to see a statistically significant (95% confidence) drop to 30%. I have scoured google and found an online calculator for a 1-sample binomial which seems to make sense.
    2) Hypothetically, if I collected data for the control (60% have A, n=100) and I also collected data for a mutant (40% have A, n=50), which statistical test(s) can I use to show significance between the control and mutant.

    I hope that makes sense! I would greatly appreciate any help
    Last edited by nufo; 10-10-2016 at 03:53 PM.

  2. #2
    TS Contributor
    Points: 12,227, Level: 72
    Level completed: 45%, Points required for next Level: 223
    rogojel's Avatar
    I work in Europe, live in Hungary
    Thanked 332 Times in 312 Posts

    Re: 1-sample binomial for my research data?

    thatbwould be a two-sample p test - you are testing a proportion in two samples, right?


+ Reply to Thread


Tags for this Thread

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts

Advertise on Talk Stats