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    Add AUCs




    I want to add Area Under the Curve (AUC) from multiple meta analyses. AUC for each Meta analysis is given. How can I add them together?

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    Re: Add AUCs

    What do you think this will accomplish
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    Re: Add AUCs

    You're right. Let me rephrase the question:
    How can I add AUCs from multiple studies into one summarized AUC. This would indicate the accracy for the diagnostic test used in these studies (assuming no bias I suppose). The aim is to compare diagnostic tests by summing studies grouped by test method.

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    Re: Add AUCs

    Lots of questions.


    Area for under the curve is based on a threshold, did all studies have the same threshold or was the threshold based on a composite of variables?


    Do you suspect heterogeneity between studies (random effects)? Was disease risk (prevalence) comparable?


    Side note, I believe that I have read that the pooling of AUC values is not always recommended, many times people will focus on pooled sensitivities and specificities.


    http://methods.cochrane.org/sites/me...May%202012.pdf


    http://methods.cochrane.org/sites/me...May%202012.pdf
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    Re: Add AUCs

    But is it not so that AUC is considering alla possible tresholds?
    Heterogeneity might be a problem. I haven't considered that yet. So, yes I need to address heterogeneity sooner or later.
    Thanks, I will look into what is recommended regarding AUC pooling.

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    Re: Add AUCs

    The receiver operator characteristic curve plots the sensitivity (y-axis) against 1-Specificity (x-axis) for a continuous variable. So yes it has all cut-offs for all continuous values in the dataset. Though, I have never seen a study make all that information available. You would have to have their raw datasets to do that. Most of the time studies present just the optimal cut-off value that maximized the AUC. If multiple studies do this, you may need to make sure they are all using the same cut-off (threshold) and that some of the study aren't controlling for other variables than others.
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    Re: Add AUCs


    Thanks! I must have a look at that when Im back in office after the christmas holliday. Meanwhile, merry cristmas!

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