noninferiority

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    Trial sequential analysis of noninferiority randomized control trials

    Hello, anyone out there familiar with Trial Sequential Analysis (TSA) software developed by Copenhagen Trial Unit? The free software is available at: http://www.ctu.dk/tsa/downloads.aspx Manual is available here: http://www.ctu.dk/tsa/files/tsa_manual.pdf Summary of my questions up here: 1. How...
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    RCT: estimation of total sample size knowing only the percentage of occurrence

    Dear all, I was asked to estimate the minimum sample size to set up a RCT comparing a standard dose technique to detect recurrence of disease vs low-dose technique. It seemed to be reasonably to me to think about differences in sensitivity and to suggest a noninferiority trial comparing the...