overall survival

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    Sample size calculation for survival clinical trial

    Hi! I need to calculate sample size for phase 3 clinical trila with following assumption: Primary Endpoint: Overall Survival (OS) in 36 months; Study Hypothesis: superiority (H0: Υ ≥ δ; H1: Υ < δ); Type I error: 2.5% (α = 0.025); Type II error: 20% (β = 0.2); Expected HR for...