trial sequential analysis

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    Questions about trial sequential analysis for non-randomized control studies (non-RCTs)

    May I ask a question on the trial sequential analysis (TSA)? It is a method of cumulative meta-analysis. Could we pooled adjusted risk ratios (aRR) in trial sequential analysis, especially for observational studies in which there are obvious differences between crude RR and adjusted RR? Now, I...
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    Trial sequential analysis of noninferiority randomized control trials

    Hello, anyone out there familiar with Trial Sequential Analysis (TSA) software developed by Copenhagen Trial Unit? The free software is available at: http://www.ctu.dk/tsa/downloads.aspx Manual is available here: http://www.ctu.dk/tsa/files/tsa_manual.pdf Summary of my questions up here: 1. How...