I have performed two logistic regression models (full model and stepwise reduced model). I have 8 predictors and 5 predictors, respectively.

Both continouos and categorical predictors and binary outcome.

Now I want to calculate average marginal effects, but will it only make sense to do it on these two models or can I also choose two variables that are clinically related and see what their AME is in a much simpler model of 2 predictors? Will it make sense to just pick relevant predictors and calculate AME two and two for example?

Do I risk to make some wrong assumptions by excluding predictors that I know are explaining some of the outcome?

My reason for doing it is because it is very hard to make clinical sense of 8 predictors in combination.

thanks