As I am very new to Biostats and research papers, I have a few questions in regards to a paper that I just read (noninferority of medicine A over D ), please explained the bolded and underscored sections:
#1. noninferiority margin of 2.00 for the upper limit of the two-sided 95% confidence interval of the hazard ratio
#2. We determined that the enrollment of 1000 patients would provide a power of 80% to show the noninferiority of A at a one-sided alpha level of 0.025, assuming an estimated 1-month incidence of the primary efficacy outcome of 7% with D.
#3 Proportional-hazards assumptions were tested with the use of a generalized Wald test for a joint hypothesis on all interaction terms specified in the statistical models
Thank you so much, please explain in layman terms, thanks!!
#1. noninferiority margin of 2.00 for the upper limit of the two-sided 95% confidence interval of the hazard ratio
#2. We determined that the enrollment of 1000 patients would provide a power of 80% to show the noninferiority of A at a one-sided alpha level of 0.025, assuming an estimated 1-month incidence of the primary efficacy outcome of 7% with D.
#3 Proportional-hazards assumptions were tested with the use of a generalized Wald test for a joint hypothesis on all interaction terms specified in the statistical models
Thank you so much, please explain in layman terms, thanks!!