1.To determine difference in 2 means (continuous outcome) for a 1:1 matched case-control study the proper test to use is either a t-test or a Wilcoxon Ranks Test. What tests can you use if you want to use regression on a 1:1 matched design? Can you use a basic linear regression model (proc reg in SAS) if all the assumptions are met? If a nonparametric model is needed, what do you recommend?

2.When trying to find the difference between 2 means (continuous outcome) in a 1:4 matched case-control study, what is the proper statistical test to use? (I know it is incorrect to use the t-test and Wilcoxon Ranks Test). Secondly, if you want to apply a regression model is there a special kind to use for 1:4 matched studies with a continuous outcome? What type do you use if all assumptions are met? If assumptions are not met is there a nonparametric version?

For a 1:1 case control study that has a dichotomous outcome it is proper to use either the McNemar’s test, a Mantel-Haenzel matched-pairs analysis. For a 1:4 matched case-control study with a categorical outcome it is correct to use the PROC PHREG (conditional logistic regression) procedure. These tests cannot be used for a 1:4 matched design with a continuous outcome variable.