Guidance needed

#1
I am in healthcare and I want to predict future volume (primarily just the end of the current month).
The problem I have with using a traditional regression is that weekends and holidays really throw off volumes.
For example, Tuesday – Thursday our volumes are the highest. Throw in a holiday near a weekend and that really throws them off e.g. this thanksgiving.
What is the best way to help predict volumes?

Thank you in advance