Hartung Method of combining dependent pvalues

hlsmith

Not a robit
#2
Can you provide an example of what you are trying to do (e.g., merge multiple ttest statistics or some type of pooling for a meta-analysis)?
 

hlsmith

Not a robit
#4
What about potential interactions between activated genes (synergy). Not sure this is an issue. I have never heard of this approach analytic approach before (though not my area). Seems like a causal diagram is needed to lay out assumptions (e.g., mediated effects, interactions, temporal relations, feedback loops, etc.).