If 51/73 (70%) patients meet the criteria of HbA1c<7%, How do I interpret the result? How do I determine the statistical significance of this result? Is the drug efficacious?

Please help. Thanks.

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If 51/73 (70%) patients meet the criteria of HbA1c<7%, How do I interpret the result? How do I determine the statistical significance of this result? Is the drug efficacious?

Please help. Thanks.

This is a 2-tailed test. You can even do the single tailed tests(involving inequality). For further reading: http://stattrek.com/lesson5/proportion.aspx

You don't necessarily need a hypothesis. The goal could just be to create a confidence interval.

I do not have an hypothesis for the study because this is the first study for the drug.

If 51/73 subject achieve the endpoint (HbA1c<7%), then using the formula (Reference: http://davidmlane.com/hyperstat/B21574.html)

p ± z σp

where σp is √p (1-p)/N

for a 95% CI the lower and upper limit is calculated as 0.602 and 0.798 (without correction for continuity)

Now, Can I say with 95% CI that the success rate of the drug falls between 60 and 79%? If yes, Can I use this value to generate a hypothesis for my next study.

Please help me with the answers. Thanks.

Since my study is the first one using the drug and since I have no experience with efficacy of the drug,

Is it possible to do the study without an hypothesis (as suggested by Dason), and then use the results as the hypothesis for the next controlled trial.