Number of possible combinations in a DNA sequence with mutations

Hi guys!

I'm a bit stuck and hopefully someone can help. :)

There is a fixed DNA sequence (242 nucleotides long) with few random mutations (5 nucleotides are different from the original sequence).

These 5 nucleotides can be different anywhere in the sequence. Let's just assume that every nucleotide (A, G, C, T) can only mutate to 1 other nucleotide and that it doesn't matter which one, so there would be simply 242 nucleotides and 5 of them are different.

how many different combinations would there be?