May I ask a question on the trial sequential analysis (TSA)? It is a method of cumulative meta-analysis.
Could we pooled adjusted risk ratios (aRR) in trial sequential analysis, especially for observational studies in which there are obvious differences between crude RR and adjusted RR?
Now, I use TSA Viewer (Version 0.9.5.10 Beta) to do it.
Free software: https://www.ctu.dk/tsa/downloads.aspx
User manual for TSA: https://www.ctu.dk/tsa/files/tsa_manual.pdf
Please look at the attached figure, it seems that only numbers of event and total subjects can be entered in it. Thus, the calculated RRs/ORs are crude measures without any adjustment. I am not quite sure whether this method/this software can pool the adjusted RRs/ORs, especially for observational studies.
Is anyone familiar with this? Better to provide reference paper to me if it is convenient for you.
Thank you very much!
Could we pooled adjusted risk ratios (aRR) in trial sequential analysis, especially for observational studies in which there are obvious differences between crude RR and adjusted RR?
Now, I use TSA Viewer (Version 0.9.5.10 Beta) to do it.
Free software: https://www.ctu.dk/tsa/downloads.aspx
User manual for TSA: https://www.ctu.dk/tsa/files/tsa_manual.pdf
Please look at the attached figure, it seems that only numbers of event and total subjects can be entered in it. Thus, the calculated RRs/ORs are crude measures without any adjustment. I am not quite sure whether this method/this software can pool the adjusted RRs/ORs, especially for observational studies.
Is anyone familiar with this? Better to provide reference paper to me if it is convenient for you.
Thank you very much!
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