Hello everyone.

I'm having trouble with biostatistics in general but particularly with finding out how to calculate what sample size i need in setting up a clinical trial with the 3 groups.

The set up is as follows:

3 groups ( placebo, low dose, high dose)

Minimal relevant change in end point: 0.3 ng/ml (pre and post measurements)

SD 0.6

alpha: 0.05

Power 80%

I'm working in SPSS (but I have access to STATA, Sigmaplot, PRISM if necessary)

Any help would be very much appreciated.

Kind regards

TK

I'm having trouble with biostatistics in general but particularly with finding out how to calculate what sample size i need in setting up a clinical trial with the 3 groups.

The set up is as follows:

3 groups ( placebo, low dose, high dose)

Minimal relevant change in end point: 0.3 ng/ml (pre and post measurements)

SD 0.6

alpha: 0.05

Power 80%

I'm working in SPSS (but I have access to STATA, Sigmaplot, PRISM if necessary)

Any help would be very much appreciated.

Kind regards

TK

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