# Study of a Statistical Method...

##### New Member
Statistical Approach Inquiry
For a statistical course, I need to understand an applied statistical method in a research paper. I have selected a research paper regarding the effect of mRNA COVID-19 vaccines in pregnant females versus in non-pregnant females. They have applied Fisher Exact as a statistical test to compare the two groups for side effects of vaccines. After reading the paper, below is my understanding of how the Fisher Exact Statistical Test was used.

Study Design and Statistical Approach
The cross-sectional study was conducted after getting an ethical review board consent for carrying out an online assessment survey, i.e., Survey Monkey, San Mateo, CA. Unidentified replies about the side effects were gathered from HCWs during the initial period of COVID-19 immunization after informed consent was obtained from the study individuals. The survey data was compiled from HCWs, who got Pfizer-BioNTech or Moderna mRNA related COVID-19 vaccines in the post vaccination stage. Out of 1029 female HCWs, 38 were pregnant. The completed survey forms were entered in the final investigation of the study. A statistical approach was achieved using Fisher exact tests to compare side-effect reported amongst pregnant and non-pregnant cohorts. Fisher's exact statistical analysis is used to conclude if there are nonrandom links among two concrete variables. The Fisher-exact significance through P-value (Bind & Rubin, 2020) matches the ratio of data of the test values as unusual or more severe than the normal test value."

Am I right? What is your opinion?

URL to the paper
https://www.ajog.org/article/S0002-9378(21)00638-4/fulltext

Link to the written online resource:
https://www.pnas.org/content/117/32/19151
https://mathworld.wolfram.com/FishersExactTest.html

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#### Karabiner

##### TS Contributor
Since they explictly state in the abstract "A statistical analysis was performed using Fisher exact tests to compare the side-effect profile between pregnant and nonpregnant groups.", what is your question, actually?

With kind regards

Karabiner

##### New Member
Since they explictly state in the abstract "A statistical analysis was performed using Fisher exact tests to compare the side-effect profile between pregnant and nonpregnant groups.", what is your question, actually?

With kind regards

Karabiner
Thanks for your question. I just clarified my post.

#### hlsmith

##### Less is more. Stay pure. Stay poor.
The groups were binary, pregnant or not pregnant. What type of variable was the outcome (dependent variable) - AKA how was it formatted?