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    Kappa for binary repeated measures

    Hi! I have two raters (patient and physician) who rate the a condition at several visits. I would like to account for inter-individual correlation when I estimate kappa. And I want to assess of there is a trend in kappa. For continuous data, the the cccrm package (R) could work. I´m unsure...
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    Change from or adjust for baseline for Binary outcomes

    Hi, any thoughts on how to estimate change from baseline, or adjust for baseline value when both the baseline value and the post-intervention value is binary. Should it be included as a covariate or should we use a logitudinal model?