false discovery rate

  1. A

    False discovery and multiple test

    I'm reading about the familywise error rate here and trying to put it into perspective. According to this, we calculate FWER = 1 - (1 - alpha)^n. In their example n=10, and with alpha .05, they say this gives 40.1% chance of a type 1 error. Is this practically saying that if i run a study and...
  2. O

    likelihood of false positive in Robust regression model. Gene expression results

    :shakehead Hi I'd like to calculate the probability of a gene A or genes A , B, C and D occuring due to chance alone in a genelist of concordant genes derived from two separate methods using the same conditions. 1. Significance of microarrays analysis of Disease v Control yielded 500 results...
  3. B

    Controlling for familywise error for large correlations matrix

    Hi there, I have 24 variables that I am currently running spearman's rank order correlations on in SPSS 19. I have read up a bit on familywise error and false discovery rate (e.g. http://www.unt.edu/rss/class/mike/5030/articles/falsediscovery2.pdf) but still do not have a clear idea on how...
  4. S

    Compare two variables : Ho = difference is 0

    Hello, This might be very trivial so please bear with me. A = [a1 a2 a3 a4] B = [b1 b2 b3 b4] Ho = [A-B]^2 = 0 i.e. A and B are the same. AND I also want to correct for False Discovery Rate (multiple comparisons) & report values (eg. [a3-b3]^2) that are significantly larger than 0...