Hi all! I am interested in estimating drug treatment effects in a crossover design where I have a baseline, week 20 and week 40 measurements (1. univariate; 2. multivariate) for a set of 30 patients. 15 of these patients were treated with active medication during the first phase (baseline to week 20) and were on placebo for the second phase (week 20 to week 40). The remaining 15 patients were on placebo for the first phase and treated with active medication in the second phase. I am interested in evaluating if the medication helped this cohort while also accounting for baseline differences, age and gender, etc. As I mentioned earlier, the recorded measurements could be univariate (e.g. mental state scores recorded at each of the three timepoints), or multivariate (e.g. thousand-dimensional imaging features estimated at each time point). I would appreciate all informed suggestions for this research question. Thank you for your time in advance!